Rprd2 MGI Mouse Gene Detail - MGI:1922387 - regulation of nuclear pre-mRNA domain containing 2

Symbol

Rprd2
Name

regulation of nuclear pre-mRNA domain containing 2
Synonyms

2810036A19Rik, 4930535B03Rik, 6720469I21Rik, mKIAA0460

Feature Type

protein coding gene
IDs

MGI:1922387
NCBI Gene: 75137
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:95667653-95726175 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 41.00 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

1175 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922387	protein coding gene	Chr3:95667183-95727034 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027594	protein coding gene	Chr3:96528899-96591583 (-)
A/J	MGP_AJ_G0027553	protein coding gene	Chr3:93513372-93571619 (-)
AKR/J	MGP_AKRJ_G0027520	protein coding gene	Chr3:95691630-95751257 (-)
BALB/cJ	MGP_BALBcJ_G0027565	protein coding gene	Chr3:93290787-93349752 (-)
C3H/HeJ	MGP_C3HHeJ_G0027298	protein coding gene	Chr3:95987732-96050664 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028013	protein coding gene	Chr3:100081208-100142186 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025353	protein coding gene	Chr3:89843245-89899041 (-)
CAST/EiJ	MGP_CASTEiJ_G0026748	protein coding gene	Chr3:95261986-95329134 (-)
CBA/J	MGP_CBAJ_G0027275	protein coding gene	Chr3:103742896-103802906 (-)
DBA/2J	MGP_DBA2J_G0027414	protein coding gene	Chr3:92801388-92860892 (-)
FVB/NJ	MGP_FVBNJ_G0027385	protein coding gene	Chr3:90881632-90941722 (-)
LP/J	MGP_LPJ_G0027523	protein coding gene	Chr3:97840926-97902564 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027412	protein coding gene	Chr3:109859987-109934369 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028067	protein coding gene	Chr3:95340553-95401670 (-)
PWK/PhJ	MGP_PWKPhJ_G0026476	protein coding gene	Chr3:92695102-92755106 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026297	protein coding gene	Chr3:93622280-93686381 (-)
WSB/EiJ	MGP_WSBEiJ_G0026830	protein coding gene	Chr3:95724680-95786281 (-)

Human Ortholog

RPRD2, regulation of nuclear pre-mRNA domain containing 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPRD2, regulation of nuclear pre-mRNA domain containing 2
Synonyms

HSPC099, KIAA0460
Links

HGNC:29039

NCBI Gene ID: 23248

neXtProt AC: NX_Q5VT52

UniProt: Q5VT52
Chr Location

1q21.2; chr1:150363091-150476566 (+) GRCh38

MGI Vertebrate Homology

Rprd2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RPRD2
Gene Tree

Rprd2

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

61
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

58
Radiation induced

1
Genomic Mutations

2 involving Rprd2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

82 strains or lines available

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

11
cDNA Data

87
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rprd2

ZFIN rprd2a

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All Sequences

75
RefSeq

16
UniProt

5
CCDS

CCDS38549.1, CCDS89669.1

Ensembl

ENSMUSG00000028106 (Evidence)
NCBI Gene

75137

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028106	Ensembl Gene Model \| MGI Sequence Detail	58523	C57BL/6J	± kb
transcript	ENSMUST00000090791	Ensembl \| MGI Sequence Detail	7756	Not Applicable
polypeptide	ENSMUSP00000088297	Ensembl \| MGI Sequence Detail	1469	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031157 regulation of nuclear pre-mRNA domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR006569 CID domain

IPR008942 ENTH/VHS

IPR032337 RPRD1A/B, C-terminal domain

IPR047885 RPRD2, CID domain
GlyGen

Q6NXI6 14 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (11 sites)

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All nucleic 87

cDNA 87

Microarray probesets 9

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MGI:1919952, MGI:1924945, MGI:2139850, MGI:2139851, MGI:2139884, MGI:2140019

Summaries

All 43

Developmental Gene Expression 2

Diseases 1

Gene Ontology 4

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rprd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34549	Chr3:95726658-95726692 (-)	-500 bp
Tssr34548	Chr3:95726523-95726559 (-)	-366 bp
Tssr34547	Chr3:95726370-95726387 (-)	-204 bp
Tssr34546	Chr3:95726253-95726302 (-)	-103 bp
Tssr34545	Chr3:95726207-95726219 (-)	-38 bp
Tssr34544	Chr3:95726133-95726189 (-)	14 bp
Tssr34543	Chr3:95726059-95726113 (-)	89 bp
Tssr34542	Chr3:95669193-95669198 (-)	56,979 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24