Rasd2 MGI Mouse Gene Detail - MGI:1922391

Symbol

Rasd2
Name

RASD family, member 2
Synonyms

4930526B11Rik, Rhes, TEM-2, TEM2

Feature Type

protein coding gene
IDs

MGI:1922391
NCBI Gene: 75141
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr8:75940572-75950741 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 35.61 cM
Mapping Data

2 experiments

SNPs within 2kb

365 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922391	protein coding gene	Chr8:75940572-75950741 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033797	protein coding gene	Chr8:75663870-75674106 (+)
A/J	MGP_AJ_G0033779	protein coding gene	Chr8:72693205-72703492 (+)
AKR/J	MGP_AKRJ_G0033706	protein coding gene	Chr8:74910882-74920988 (+)
BALB/cJ	MGP_BALBcJ_G0033773	protein coding gene	Chr8:72786102-72796442 (+)
C3H/HeJ	MGP_C3HHeJ_G0033482	protein coding gene	Chr8:75475168-75485443 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034293	protein coding gene	Chr8:78595366-78610735 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031234	protein coding gene	Chr8:66955877-66965868 (+)
CAST/EiJ	MGP_CASTEiJ_G0032811	protein coding gene	Chr8:74748424-74762514 (+)
CBA/J	MGP_CBAJ_G0033461	protein coding gene	Chr8:81363680-81373896 (+)
DBA/2J	MGP_DBA2J_G0033615	protein coding gene	Chr8:72379100-72389332 (+)
FVB/NJ	MGP_FVBNJ_G0033560	protein coding gene	Chr8:71453683-71463606 (+)
LP/J	MGP_LPJ_G0033704	protein coding gene	Chr8:75797456-75807667 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033603	protein coding gene	Chr8:83912178-83922410 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034310	protein coding gene	Chr8:74871060-74881299 (+)
PWK/PhJ	MGP_PWKPhJ_G0032517	protein coding gene	Chr8:71648280-71658558 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032355	protein coding gene	Chr8:73753585-73768781 (+)
WSB/EiJ	MGP_WSBEiJ_G0032926	protein coding gene	Chr8:75190401-75200623 (+)

Human Ortholog

RASD2, RASD family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RASD2, RASD family member 2
Synonyms

Rhes, TEM2
Links

HGNC:18229

NCBI Gene ID: 23551

neXtProt AC: NX_Q96D21

UniProt: Q96D21
Chr Location

22q12.3; chr22:35532806-35553999 (+) GRCh38

MGI Vertebrate Homology

Rasd2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RASD2
Gene Tree

Rasd2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Rasd2
Incidental Mutations

CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display reduced body weight, impaired motor coordination, hypoactivity, and a gender-dependent increase in anxiety levels.

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All GO Annotations

19
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

22
cDNA Data

15
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rasd2

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS52602.1

Ensembl

ENSMUSG00000034472 (Evidence)
NCBI Gene

75141

			Length	Strain/Species	Flank
genomic	75141	NCBI Gene Model \| MGI Sequence Detail	10170	C57BL/6J	± kb
transcript	NM_029182	RefSeq \| MGI Sequence Detail	3316	C57BL/6
polypeptide	P63032	UniProt \| EBI \| MGI Sequence Detail	266	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013751 GTP-binding protein Rhes

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR052236 Small GTPase RasD

IPR005225 Small GTP-binding protein domain

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All nucleic 22

Genomic 4

cDNA 15

Primer pair 3

Microarray probesets 3

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MGI:2142722

Summaries

All 54

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 20
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:347831 Pan Y, et al., Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model. Front Aging Neurosci. 2023;15:1237018

TSS for Rasd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78082	Chr8:75939807-75939885 (+)	-726 bp
Tssr78083	Chr8:75939887-75939913 (+)	-672 bp
Tssr78084	Chr8:75939916-75939925 (+)	-651 bp
Tssr78085	Chr8:75939953-75939962 (+)	-614 bp
Tssr78086	Chr8:75939984-75939997 (+)	-581 bp
Tssr78087	Chr8:75940058-75940089 (+)	-498 bp
Tssr78088	Chr8:75940110-75940120 (+)	-457 bp
Tssr78089	Chr8:75945911-75945926 (+)	5,347 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24