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Pdzd2 Gene Detail
Summary
  • Symbol
    Pdzd2
  • Name
    PDZ domain containing 2
  • Synonyms
    4930537L06Rik, A930022H17Rik, Gm21706, LOC223364, mKIAA0300, Pdzk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922394
    NCBI Gene: 68070
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:12359797-12740010 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 5.90 cM, cytoband A2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11495 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922394
 protein coding gene Chr15:12359797-12740052 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021738
 protein coding gene Chr15:9597834-9843652 (-)
A/J MGP_AJ_G0021698
 protein coding gene Chr15:9291638-9671982 (-)
AKR/J MGP_AKRJ_G0021676
 protein coding gene Chr15:9546562-9950484 (-)
BALB/cJ MGP_BALBcJ_G0021705
 protein coding gene Chr15:9198802-9582092 (-)
C3H/HeJ MGP_C3HHeJ_G0021481
 protein coding gene Chr15:9500979-9889666 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022144
 protein coding gene Chr15:9943617-10343915 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019685
 protein coding gene Chr15:8821081-9052894 (-)
CAST/EiJ MGP_CASTEiJ_G0020997
 protein coding gene Chr15:9594464-9859983 (-)
CBA/J MGP_CBAJ_G0021450
 protein coding gene Chr15:10231297-10663387 (-)
DBA/2J MGP_DBA2J_G0021574
 protein coding gene Chr15:9149055-9528857 (-)
FVB/NJ MGP_FVBNJ_G0021552
 protein coding gene Chr15:8998086-9382664 (-)
LP/J MGP_LPJ_G0021642
 protein coding gene Chr15:9518600-9768647 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021577
 protein coding gene Chr15:10468202-10718016 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022167
 protein coding gene Chr15:9553968-9799230 (-)
PWK/PhJ MGP_PWKPhJ_G0020740
 protein coding gene Chr15:9326050-9568858 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020578
 protein coding gene Chr15:9477092-9723488 (-)
WSB/EiJ MGP_WSBEiJ_G0021053
 protein coding gene Chr15:9535245-9782057 (-)



Homology
more
  • Human Ortholog
    PDZD2, PDZ domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDZD2, PDZ domain containing 2
  • Synonyms
    AIPC, PAPIN, PDZK3, PIN1
  • Links
    NCBI Gene ID: 23037
    neXtProt AC: NX_O15018
    UniProt: O15018

  • Chr Location
    5p13.3; chr5:31639131-32110932 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit normal response to acute and chronic pain. Mice homozygous for a different gene trap allele exhibit increased basal insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    7
  • cDNA Data
    45
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022197 Ensembl Gene Model | MGI Sequence Detail 380214 C57BL/6J ±  kb
    transcript ENSMUST00000075317 Ensembl | MGI Sequence Detail 10756 Not Applicable  
    polypeptide ENSMUSP00000074788 Ensembl | MGI Sequence Detail 2796 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR001478 PDZ domain
      IPR036034 PDZ superfamily
    • GlyGen
      E9Q1M1 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 45
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1915320, MGI:2684928, MGI:5435061
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory