Spaca6 MGI Mouse Gene Detail - MGI:1922452 - sperm acrosome associated 6

Symbol

Spaca6
Name

sperm acrosome associated 6
Synonyms

4930546H06Rik, B230206P06Rik, Ncrna00085

Feature Type

protein coding gene
IDs

MGI:1922452
NCBI Gene: 75202
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr17:18047420-18063271 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 10.50 cM, cytoband A3.1
Mapping Data

2 experiments

SNPs within 2kb

375 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922452	protein coding gene	Chr17:18045955-18063274 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023184	protein coding gene	Chr17:15836808-15849437 (+)
A/J	MGP_AJ_G0023149	protein coding gene	Chr17:15482312-15494618 (+)
AKR/J	MGP_AKRJ_G0023119	protein coding gene	Chr17:15557944-15570272 (+)
BALB/cJ	MGP_BALBcJ_G0023149	protein coding gene	Chr17:15427764-15440087 (+)
C3H/HeJ	MGP_C3HHeJ_G0022909	protein coding gene	Chr17:15774418-15786727 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023592	protein coding gene	Chr17:16624291-16636581 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021104	protein coding gene	Chr17:13331162-13341785 (+)
CAST/EiJ	MGP_CASTEiJ_G0022428	protein coding gene	Chr17:15585531-15597875 (+)
CBA/J	MGP_CBAJ_G0022886	protein coding gene	Chr17:17193172-17205482 (+)
DBA/2J	MGP_DBA2J_G0023019	protein coding gene	Chr17:15196655-15208970 (+)
FVB/NJ	MGP_FVBNJ_G0022987	protein coding gene	Chr17:15007259-15019690 (+)
LP/J	MGP_LPJ_G0023093	protein coding gene	Chr17:15830999-15843316 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023008	protein coding gene	Chr17:16776730-16790065 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023629	protein coding gene	Chr17:15744595-15756913 (+)
PWK/PhJ	MGP_PWKPhJ_G0022177	protein coding gene	Chr17:14828335-14840852 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022005	protein coding gene	Chr17:14831177-14843391 (+)
WSB/EiJ	MGP_WSBEiJ_G0022487	protein coding gene	Chr17:16033575-16045922 (+)

Human Ortholog

SPACA6, sperm acrosome associated 6

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPACA6, sperm acrosome associated 6
Synonyms

LET7EH, LINC00085, NCRNA00085, SPACA6P
Links

HGNC:27113

NCBI Gene ID: 147650

neXtProt AC: NX_W5XKT8

UniProt: W5XKT8
Chr Location

19q13.41; chr19:51682686-51713143 (+) GRCh38

MGI Vertebrate Homology

Spaca6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPACA6
Gene Tree

Spaca6

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Phenotype Summary

3 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

3
Gene trapped

18
Targeted

2
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgene insertion that inactivates this gene exhibit impaired fertilization and male infertility. Mice homozygous for a null allele show male infertility due to inability of spermatozoa to fuse with the oocyte membrane.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

98
RefSeq

36
UniProt

7
CCDS

CCDS49967.1

Ensembl

ENSMUSG00000080316 (Evidence)
NCBI Gene

75202

			Length	Strain/Species	Flank
genomic	ENSMUSG00000080316	Ensembl Gene Model \| MGI Sequence Detail	15852	C57BL/6J	± kb
transcript	ENSMUST00000172097	Ensembl \| MGI Sequence Detail	1073	Not Applicable
polypeptide	ENSMUSP00000128732	Ensembl \| MGI Sequence Detail	339	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000060144 sperm acrosome membrane-associated protein 6

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR034549 Sperm acrosome membrane-associated protein 6
GlyGen

E9Q8Q8 1 site

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All nucleic 19

cDNA 19

Microarray probesets 4

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MGI:1926095

Summaries

All 35

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:337404 Matsumura T, et al., Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Front Cell Dev Biol. 2021;9:810118

TSS for Spaca6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142801	Chr17:18047209-18047226 (+)	-202 bp
Tssr5018	Chr17:18047355-18047383 (+)	-51 bp
Tssr142802	Chr17:18047396-18047425 (+)	-9 bp
Tssr142805	Chr17:18051309-18051331 (+)	3,900 bp
Tssr142806	Chr17:18051338-18051357 (+)	3,928 bp
Tssr142807	Chr17:18051399-18051407 (+)	3,983 bp
Tssr142808	Chr17:18051560-18051578 (+)	4,149 bp
Tssr5019	Chr17:18051904-18051916 (+)	4,490 bp
Tssr5020	Chr17:18052721-18052735 (+)	5,308 bp
Tssr142809	Chr17:18053233-18053237 (+)	5,815 bp
Tssr142810	Chr17:18058333-18058350 (+)	10,922 bp
Tssr142811	Chr17:18058570-18058595 (+)	11,163 bp
Tssr142812	Chr17:18058651-18058705 (+)	11,258 bp
Tssr142813	Chr17:18058719-18058737 (+)	11,308 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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