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Exd2 Gene Detail
Summary
  • Symbol
    Exd2
  • Name
    exonuclease 3'-5' domain containing 2
  • Synonyms
    4930539P14Rik, Exdl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922485
    NCBI Gene: 97827
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:80509869-80544909 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 36.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    697 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922485
 protein coding gene Chr12:80509869-80547001 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019888
 protein coding gene Chr12:80821829-80860663 (+)
A/J MGP_AJ_G0019846
 protein coding gene Chr12:77896248-77935589 (+)
AKR/J MGP_AKRJ_G0019821
 protein coding gene Chr12:80026070-80064338 (+)
BALB/cJ MGP_BALBcJ_G0019825
 protein coding gene Chr12:78152017-78188481 (+)
C3H/HeJ MGP_C3HHeJ_G0019631
 protein coding gene Chr12:80495253-80533618 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020277
 protein coding gene Chr12:83191506-83235145 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017896
 protein coding gene Chr12:74893581-74929873 (+)
CAST/EiJ MGP_CASTEiJ_G0019181
 protein coding gene Chr12:75350622-75388866 (+)
CBA/J MGP_CBAJ_G0019602
 protein coding gene Chr12:86446333-86487795 (+)
DBA/2J MGP_DBA2J_G0019717
 protein coding gene Chr12:77512802-77548868 (+)
FVB/NJ MGP_FVBNJ_G0019703
 protein coding gene Chr12:76335644-76370757 (+)
LP/J MGP_LPJ_G0019789
 protein coding gene Chr12:80756928-80795919 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019742
 protein coding gene Chr12:89465425-89506624 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020312
 protein coding gene Chr12:79554151-79592281 (+)
PWK/PhJ MGP_PWKPhJ_G0018947
 protein coding gene Chr12:71901728-71938281 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018741
 protein coding gene Chr12:74046344-74085055 (+)
WSB/EiJ MGP_WSBEiJ_G0019234
 protein coding gene Chr12:80196422-80234876 (+)



Homology
more
  • Human Ortholog
    EXD2, exonuclease 3'-5' domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXD2, exonuclease 3'-5' domain containing 2
  • Synonyms
    C14orf114, EXDL2
  • Links
    NCBI Gene ID: 55218
    neXtProt AC: NX_Q9NVH0
    UniProt: Q9NVH0

  • Chr Location
    14q24.1; chr14:69191498-69244020 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Mice homozygous for a mutation in the exonuclease domain of the gene are viable, overtly normal, and exhibit normal male fertility, despite misregulation of PIWI-interacting RNAs (piRNA) levels originating from specific pachytene piRNA clusters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    10
  • cDNA Data
    69
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 97827 NCBI Gene Model | MGI Sequence Detail 35041 C57BL/6J ±  kb
transcript NM_133798 RefSeq | MGI Sequence Detail 3323 C57BL/6  
polypeptide Q8VEG4 UniProt | EBI | MGI Sequence Detail 650 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145119
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345489 Olotu O, et al., Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes. Andrology. 2023 May;11(4):710-723
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory