Ndufs7 MGI Mouse Gene Detail - MGI:1922656 - NADH:ubiquinone oxidoreductase core subunit S7

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Ndufs7 Gene Detail

Symbol

Ndufs7
Name

NADH:ubiquinone oxidoreductase core subunit S7
Synonyms

1010001M04Rik

Feature Type

protein coding gene
IDs

MGI:1922656
NCBI Gene: 75406
Alliance

gene page
Transcription Start Sites

3 TSS
Candidate for QTL

3 QTL

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Sequence Map

Chr10:80084955-80092628 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

3 experiments

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SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1922656	protein coding gene	Chr10:80084939-80092628 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017490	protein coding gene	Chr10:80844848-80852521 (+)
A/J	MGP_AJ_G0017468	protein coding gene	Chr10:78013364-78021037 (+)
AKR/J	MGP_AKRJ_G0017429	protein coding gene	Chr10:80143694-80151367 (+)
BALB/cJ	MGP_BALBcJ_G0017430	protein coding gene	Chr10:78244531-78252204 (+)
C3H/HeJ	MGP_C3HHeJ_G0017253	protein coding gene	Chr10:80240830-80248503 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017884	protein coding gene	Chr10:83634312-83641987 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015572	protein coding gene	Chr10:74236413-74244019 (+)
CAST/EiJ	MGP_CASTEiJ_G0016820	protein coding gene	Chr10:80446004-80453684 (+)
CBA/J	MGP_CBAJ_G0017225	protein coding gene	Chr10:86876115-86883788 (+)
DBA/2J	MGP_DBA2J_G0017331	protein coding gene	Chr10:77234155-77241828 (+)
FVB/NJ	MGP_FVBNJ_G0017325	protein coding gene	Chr10:76419246-76426919 (+)
LP/J	MGP_LPJ_G0017402	protein coding gene	Chr10:81319100-81326773 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017351	protein coding gene	Chr10:88819024-88826697 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017925	protein coding gene	Chr10:80128789-80136462 (+)
PWK/PhJ	MGP_PWKPhJ_G0016601	protein coding gene	Chr10:77101207-77108862 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016390	protein coding gene	Chr10:79110333-79117982 (+)
WSB/EiJ	MGP_WSBEiJ_G0016880	protein coding gene	Chr10:80166104-80173769 (+)

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Human Ortholog

NDUFS7, NADH:ubiquinone oxidoreductase core subunit S7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDUFS7, NADH:ubiquinone oxidoreductase core subunit S7
Synonyms

CI-20, CI-20KD, MC1DN3, MY017, PSST
Links

HGNC:7714

NCBI Gene ID: 374291

neXtProt AC: NX_O75251

UniProt: O75251
Chr Location

19p13.3; chr19:1383527-1395589 (+) GRCh38

MGI Vertebrate Homology

Ndufs7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NDUFS7
Gene Tree

Ndufs7

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Diseases

2 with human NDUFS7 associations

				Human Disease	Mouse Models
				developmental disorder of mental health IDs developmental disorder of mental health DOID:0060037
				nuclear type mitochondrial complex I deficiency 3 IDs nuclear type mitochondrial complex I deficiency 3 DOID:0112093 OMIM:618224

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

8
Targeted

4
Genomic Mutations

1 involving Ndufs7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

30
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

820
Tissues

107
cDNA Data

8
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ndufs7

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All Sequences

42
RefSeq

8
UniProt

1
CCDS

CCDS24015.1

Ensembl

ENSMUSG00000020153 (Evidence)
NCBI Gene

75406

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000020153	Ensembl Gene Model \| MGI Sequence Detail	7674	C57BL/6J	± kb
	transcript	ENSMUST00000105364	Ensembl \| MGI Sequence Detail	983	Not Applicable
	polypeptide	ENSMUSP00000101003	Ensembl \| MGI Sequence Detail	224	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000023430 NADH-quinone oxidoreductase subunit B

(term hierarchy)
PDB

6G2J, 6G72, 6ZR2, 6ZTQ, 7AK5, 7AK6, 7B93, 7PSA, 8C2S, 8CA3, 8CA5, 8OLT, 8OM1, 8PW5, 8PW6, 8PW7, 8RGP, 8RGQ, 8RGR, 8RGT
EC

7.1.1.2
InterPro Domains

IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit

IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit
GlyGen

Q9DC70 1 site, 1 O-linked glycan (1 site)

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All nucleic 11

cDNA 8

Primer pair 3

Microarray probesets 4

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Summaries

All 54

Developmental Gene Expression 3

Gene Ontology 13

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071

TSS for Ndufs7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94526	Chr10:80084940-80084958 (+)	-6 bp
Tssr94528	Chr10:80085275-80085302 (+)	334 bp
Tssr94529	Chr10:80089518-80089554 (+)	4,581 bp

Ndufs7 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bgeq8	Chr10, 66.75 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Igfbp3q2	Chr10, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Insq9	Chr10, 39.72 cM	Chr10:82490938-82491121	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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