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Rspo2 Gene Detail
Summary
  • Symbol
    Rspo2
  • Name
    R-spondin 2
  • Synonyms
    2610028F08Rik, FLTL, ftls, Int7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922667
    NCBI Gene: 239405
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:42884190-43034222 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 16.73 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3948 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922667
 protein coding gene Chr15:42884184-43034990 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021824
 protein coding gene Chr15:41596128-41751754 (-)
A/J MGP_AJ_G0021784
 protein coding gene Chr15:39997958-40148891 (-)
AKR/J MGP_AKRJ_G0021765
 protein coding gene Chr15:41195785-41353273 (-)
BALB/cJ MGP_BALBcJ_G0021791
 protein coding gene Chr15:40080138-40229001 (-)
C3H/HeJ MGP_C3HHeJ_G0021565
 protein coding gene Chr15:41108751-41258787 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022230
 protein coding gene Chr15:43207819-43365253 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019767
 protein coding gene Chr15:37600042-37745445 (-)
CAST/EiJ MGP_CASTEiJ_G0021082
 protein coding gene Chr15:41636983-41791028 (-)
CBA/J MGP_CBAJ_G0021534
 protein coding gene Chr15:44705023-44870296 (-)
DBA/2J MGP_DBA2J_G0021658
 protein coding gene Chr15:39833564-39981712 (-)
FVB/NJ MGP_FVBNJ_G0021636
 protein coding gene Chr15:39155096-39300935 (-)
LP/J MGP_LPJ_G0021728
 protein coding gene Chr15:41393609-41537335 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021660
 protein coding gene Chr15:47811030-47973292 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022253
 protein coding gene Chr15:41390845-41539998 (-)
PWK/PhJ MGP_PWKPhJ_G0020827
 protein coding gene Chr15:39870032-40012737 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020664
 protein coding gene Chr15:41039083-41193266 (-)
WSB/EiJ MGP_WSBEiJ_G0021137
 protein coding gene Chr15:41265655-41421974 (-)



Homology
more
  • Human Ortholog
    RSPO2, R-spondin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RSPO2, R-spondin 2
  • Synonyms
    CRISTIN2, HHRRD, TETAMS2
  • Links
    NCBI Gene ID: 340419
    neXtProt AC: NX_Q6UXX9
    UniProt: Q6UXX9

  • Chr Location
    8q23.1; chr8:107899316-108083642 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RSPO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 4 alleles in 5 genetic backgrounds
    22 phenotypes from multigenic genotypes
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display perinatal lethality, cleft palate, lung hypoplasia, asymmetric limb malformations and abnormal renal development. Heterozygous females display reduced fertility with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1275
  • Tissues
    344
  • cDNA Data
    38
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051920 Ensembl Gene Model | MGI Sequence Detail 150033 C57BL/6J ±  kb
    transcript ENSMUST00000226810 Ensembl | MGI Sequence Detail 3091 Not Applicable  
    polypeptide ENSMUSP00000154600 Ensembl | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 38
      Primer pair 13
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145926, MGI:3045969
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 57
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:352941 Liu Y, et al., KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3. Sci Adv. 2024 May 17;10(20):eadm9326
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory