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Tti1 Gene Detail
Summary
  • Symbol
    Tti1
  • Name
    TELO2 interacting protein 1
  • Synonyms
    2610036D13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922675
    NCBI Gene: 75425
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157823723-157870353 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922675
 protein coding gene Chr2:157823723-157870382 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026787
 protein coding gene Chr2:163024550-163074590 (-)
A/J MGP_AJ_G0026753
 protein coding gene Chr2:156495919-156543083 (-)
AKR/J MGP_AKRJ_G0026724
 protein coding gene Chr2:161118116-161164588 (-)
BALB/cJ MGP_BALBcJ_G0026762
 protein coding gene Chr2:156800830-156847707 (-)
C3H/HeJ MGP_C3HHeJ_G0026504
 protein coding gene Chr2:161420959-161470757 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027211
 protein coding gene Chr2:167875981-167922942 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024581
 protein coding gene Chr2:149937634-149988353 (-)
CAST/EiJ MGP_CASTEiJ_G0025966
 protein coding gene Chr2:161781330-161828020 (-)
CBA/J MGP_CBAJ_G0026481
 protein coding gene Chr2:173907087-173956675 (-)
DBA/2J MGP_DBA2J_G0026619
 protein coding gene Chr2:155672149-155719082 (-)
FVB/NJ MGP_FVBNJ_G0026586
 protein coding gene Chr2:154072977-154119577 (-)
LP/J MGP_LPJ_G0026722
 protein coding gene Chr2:163108685-163158750 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026607
 protein coding gene Chr2:177730695-177778263 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027267
 protein coding gene Chr2:160921761-160970642 (-)
PWK/PhJ MGP_PWKPhJ_G0025700
 protein coding gene Chr2:155189356-155236644 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025503
 protein coding gene Chr2:159852403-159899226 (-)
WSB/EiJ MGP_WSBEiJ_G0026036
 protein coding gene Chr2:161829632-161878021 (-)



Homology
more
  • Human Ortholog
    TTI1, TELO2 interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTI1, TELO2 interacting protein 1
  • Synonyms
    KIAA0406, NEDMIM, smg-10
  • Links
    NCBI Gene ID: 9675
    neXtProt AC: NX_O43156
    UniProt: O43156

  • Chr Location
    20q11.23; chr20:37983007-38033461 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro, blastocysts hatch from the zona pellucida and form typical outgrowth colonies after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027650 Ensembl Gene Model | MGI Sequence Detail 46631 C57BL/6J ±  kb
    transcript ENSMUST00000109522 Ensembl | MGI Sequence Detail 3765 Not Applicable  
    polypeptide ENSMUSP00000105148 Ensembl | MGI Sequence Detail 1085 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138955
    References
    more
    • Summaries
      All 35
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:212482 Rao F, et al., Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell. 2014 Apr 10;54(1):119-32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory