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Ascc2 Gene Detail
Summary
  • Symbol
    Ascc2
  • Name
    activating signal cointegrator 1 complex subunit 2
  • Synonyms
    1700011I11Rik, 2610034L15Rik, ASC1p100
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922702
    NCBI Gene: 75452
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4587747-4635699 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1057 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922702
 protein coding gene Chr11:4587698-4635699 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017985
 protein coding gene Chr11:1606490-1658513 (+)
A/J MGP_AJ_G0017958
 protein coding gene Chr11:1586544-1632664 (+)
AKR/J MGP_AKRJ_G0017922
 protein coding gene Chr11:1654830-1702366 (+)
BALB/cJ MGP_BALBcJ_G0017926
 protein coding gene Chr11:1563123-1610037 (+)
C3H/HeJ MGP_C3HHeJ_G0017739
 protein coding gene Chr11:1548659-1596884 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018378
 protein coding gene Chr11:1682501-1729665 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016036
 protein coding gene Chr11:1481613-1527689 (+)
CAST/EiJ MGP_CASTEiJ_G0017301
 protein coding gene Chr11:1521895-1570863 (+)
CBA/J MGP_CBAJ_G0017714
 protein coding gene Chr11:1944060-1998412 (+)
DBA/2J MGP_DBA2J_G0017824
 protein coding gene Chr11:1489602-1536327 (+)
FVB/NJ MGP_FVBNJ_G0017816
 protein coding gene Chr11:1528683-1576692 (+)
LP/J MGP_LPJ_G0017895
 protein coding gene Chr11:1700370-1751259 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017842
 protein coding gene Chr11:1620355-1671715 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018418
 protein coding gene Chr11:1662633-1708819 (+)
PWK/PhJ MGP_PWKPhJ_G0017081
 protein coding gene Chr11:1499964-1546140 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016878
 protein coding gene Chr11:1628593-1680284 (+)
WSB/EiJ MGP_WSBEiJ_G0017355
 protein coding gene Chr11:1533448-1586426 (+)



Homology
more
  • Human Ortholog
    ASCC2, activating signal cointegrator 1 complex subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASCC2, activating signal cointegrator 1 complex subunit 2
  • Synonyms
    ASC1p100, p100
  • Links
    NCBI Gene ID: 84164
    neXtProt AC: NX_Q9H1I8
    UniProt: Q9H1I8

  • Chr Location
    22q12.2; chr22:29788609-29838304 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    27
  • cDNA Data
    90
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020412 Ensembl Gene Model | MGI Sequence Detail 47953 C57BL/6J ±  kb
    transcript ENSMUST00000070257 Ensembl | MGI Sequence Detail 2650 Not Applicable  
    polypeptide ENSMUSP00000063272 Ensembl | MGI Sequence Detail 749 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004360 activating signal cointegrator 1 complex subunit 2
      (term hierarchy)
    • InterPro Domains
      IPR052586 Activating signal cointegrator 1 complex subunit 2
      IPR041800 Activating signal cointegrator 1 complex subunit 2, CUE domain
      IPR009060 UBA-like superfamily
      IPR003892 Ubiquitin system component CUE
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 90

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923619, MGI:2144198, MGI:2144481
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory