Cklf MGI Mouse Gene Detail - MGI:1922708

Symbol

Cklf
Name

chemokine-like factor
Synonyms

1700001C14Rik, A730028G07Rik, C32, chemokine-like factor 4, CKLF1, CKLF2, CKLF3, CKLF4, CKLF5, Cklf6, HSPC224, UCK-1

Feature Type

protein coding gene
IDs

MGI:1922708
NCBI Gene: 75458
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:104977493-104991570 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.04 cM
Mapping Data

1 experiment

SNPs within 2kb

526 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922708	protein coding gene	Chr8:104977493-104992642 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034003	protein coding gene	Chr8:106364884-106385888 (+)
A/J	MGP_AJ_G0033984	protein coding gene	Chr8:102140078-102155241 (+)
AKR/J	MGP_AKRJ_G0033911	protein coding gene	Chr8:105099597-105114429 (+)
BALB/cJ	MGP_BALBcJ_G0033977	protein coding gene	Chr8:102371170-102383615 (+)
C3H/HeJ	MGP_C3HHeJ_G0033689	protein coding gene	Chr8:105797577-105816400 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034498	protein coding gene	Chr8:110270157-110285613 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031441	protein coding gene	Chr8:95451789-95464603 (+)
CAST/EiJ	MGP_CASTEiJ_G0033019	protein coding gene	Chr8:105376295-105397224 (+)
CBA/J	MGP_CBAJ_G0033663	protein coding gene	Chr8:113898421-113919088 (+)
DBA/2J	MGP_DBA2J_G0033817	protein coding gene	Chr8:101505510-101522689 (+)
FVB/NJ	MGP_FVBNJ_G0033764	protein coding gene	Chr8:100443458-100458044 (+)
LP/J	MGP_LPJ_G0033908	protein coding gene	Chr8:106547688-106569163 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033806	protein coding gene	Chr8:117091051-117100118 (+)
NZO/HlLtJ	no annotation
PWK/PhJ	MGP_PWKPhJ_G0032720	protein coding gene	Chr8:100917022-100932874 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032558	protein coding gene	Chr8:103891342-103907839 (+)
WSB/EiJ	MGP_WSBEiJ_G0033132	protein coding gene	Chr8:105736629-105751253 (+)

Human Ortholog

CKLF, chemokine like factor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CKLF, chemokine like factor
Synonyms

C32, CKLF1, CKLF2, CKLF3, CKLF4, HSPC224, UCK-1
Links

HGNC:13253

NCBI Gene ID: 51192

neXtProt AC: NX_Q9UBR5

UniProt: Q9UBR5
Chr Location

16q21; chr16:66552563-66566287 (+) GRCh38

MGI Vertebrate Homology

Cklf stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CKLF
Gene Tree

Cklf

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a null allele exhibit complete preweaning lethality.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

71
RefSeq

12
UniProt

4
CCDS

CCDS40449.1, CCDS40450.1, CCDS85592.1

Ensembl

ENSMUSG00000054400 (Evidence)
NCBI Gene

75458

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054400	Ensembl Gene Model \| MGI Sequence Detail	14078	C57BL/6J	± kb
transcript	ENSMUST00000034342	Ensembl \| MGI Sequence Detail	667	Not Applicable
polypeptide	ENSMUSP00000034342	Ensembl \| MGI Sequence Detail	152	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005514 chemokine-like factor

(term hierarchy)
InterPro Domains

IPR008253 Marvel domain

IPR050578 MARVEL domain-containing and chemokine-like factor proteins

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All nucleic 13

cDNA 13

Microarray probesets 13

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MGI:2443587

Summaries

All 38

Gene Ontology 7

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:335273 Ma WY, et al., A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke. J Neuroinflammation. 2023 Apr 25;20(1):97

TSS for Cklf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79037	Chr8:104977501-104977544 (+)	30 bp
Tssr79038	Chr8:104977557-104977572 (+)	72 bp
Tssr79039	Chr8:104977575-104977586 (+)	88 bp
Tssr79040	Chr8:104977592-104977603 (+)	105 bp
Tssr2673	Chr8:104977621-104977630 (+)	133 bp
Tssr79041	Chr8:104991100-104991108 (+)	13,611 bp
Tssr79042	Chr8:104991114-104991140 (+)	13,634 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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