About   Help   FAQ
Syce3 Gene Detail
Summary
  • Symbol
    Syce3
  • Name
    synaptonemal complex central element protein 3
  • Synonyms
    1700007E06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922709
    NCBI Gene: 75459
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89274377-89294706 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    698 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922709
 protein coding gene Chr15:89274377-89294706 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022233
 protein coding gene Chr15:90582690-90605605 (-)
A/J MGP_AJ_G0022192
 protein coding gene Chr15:87118164-87140675 (-)
AKR/J MGP_AKRJ_G0022167
 protein coding gene Chr15:89696256-89719952 (-)
BALB/cJ MGP_BALBcJ_G0022198
 protein coding gene Chr15:87223001-87244527 (-)
C3H/HeJ MGP_C3HHeJ_G0021968
 protein coding gene Chr15:89692905-89715904 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022643
 protein coding gene Chr15:93873029-93897344 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020168
 protein coding gene Chr15:83345260-83365264 (-)
CAST/EiJ MGP_CASTEiJ_G0021490
 protein coding gene Chr15:90469504-90493285 (-)
CBA/J MGP_CBAJ_G0021935
 protein coding gene Chr15:97058960-97081183 (-)
DBA/2J MGP_DBA2J_G0022062
 protein coding gene Chr15:86568435-86590726 (-)
FVB/NJ MGP_FVBNJ_G0022041
 protein coding gene Chr15:85634023-85659206 (-)
LP/J MGP_LPJ_G0022133
 protein coding gene Chr15:90739465-90761398 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022061
 protein coding gene Chr15:101456786-101480523 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022658
 protein coding gene Chr15:89731962-89754845 (-)
PWK/PhJ MGP_PWKPhJ_G0021231
 protein coding gene Chr15:86631283-86652501 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021065
 protein coding gene Chr15:89480732-89503145 (-)
WSB/EiJ MGP_WSBEiJ_G0021539
 protein coding gene Chr15:90220642-90244196 (-)



Homology
more
  • Human Ortholog
    SYCE3, synaptonemal complex central element protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYCE3, synaptonemal complex central element protein 3
  • Synonyms
    C22orf41, THEG2
  • Links
    NCBI Gene ID: 644186
    neXtProt AC: NX_A1L190
    UniProt: A1L190

  • Chr Location
    22q13.33; chr22:50551112-50562919 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    5 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display male and female infertility, impaired double strand break repair and absence of synapsis during meiosis, absence of mature gametes, and small testes and ovaries.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    13
  • cDNA Data
    8
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75459 NCBI Gene Model | MGI Sequence Detail 20330 C57BL/6J ±  kb
    transcript NM_001162880 RefSeq | MGI Sequence Detail 510 Not Specified  
    polypeptide B5KM66 UniProt | EBI | MGI Sequence Detail 88 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 6
      Phenotypes 25
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:285969 Liu H, et al., SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. Nucleic Acids Res. 2019 Jun 20;47(11):5670-5683
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory