Stpg4 MGI Mouse Gene Detail - MGI:1922717 - sperm tail PG rich repeat containing 4

Symbol

Stpg4
Name

sperm tail PG rich repeat containing 4
Synonyms

1700011E24Rik

Feature Type

protein coding gene
IDs

MGI:1922717
NCBI Gene: 75467
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:87696999-87735169 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 57.38 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

1268 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922717	protein coding gene	Chr17:87696998-87735526 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024102	protein coding gene	Chr17:90775456-90818553 (-)
A/J	MGP_AJ_G0024061	protein coding gene	Chr17:87850718-87894564 (-)
AKR/J	MGP_AKRJ_G0024030	protein coding gene	Chr17:89327553-89370336 (-)
BALB/cJ	MGP_BALBcJ_G0024062	protein coding gene	Chr17:87701609-87744784 (-)
C3H/HeJ	MGP_C3HHeJ_G0023827	protein coding gene	Chr17:90199708-90243903 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024507	protein coding gene	Chr17:93903312-93941651 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021946	protein coding gene	Chr17:82992369-83033490 (-)
CAST/EiJ	MGP_CASTEiJ_G0023306	protein coding gene	Chr17:91031291-91078038 (-)
CBA/J	MGP_CBAJ_G0023801	protein coding gene	Chr17:97847367-97893051 (-)
DBA/2J	MGP_DBA2J_G0023929	protein coding gene	Chr17:86285637-86324211 (-)
FVB/NJ	MGP_FVBNJ_G0023895	protein coding gene	Chr17:85798713-85840099 (-)
LP/J	MGP_LPJ_G0024013	protein coding gene	Chr17:91559938-91610675 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023923	protein coding gene	Chr17:97721566-97765148 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024552	protein coding gene	Chr17:89844498-89889425 (-)
PWK/PhJ	MGP_PWKPhJ_G0023051	protein coding gene	Chr17:85929130-85968946 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022862	protein coding gene	Chr17:86589447-86629967 (-)
WSB/EiJ	MGP_WSBEiJ_G0023372	protein coding gene	Chr17:90686929-90733075 (-)

Human Ortholog

STPG4, sperm-tail PG-rich repeat containing 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STPG4, sperm-tail PG-rich repeat containing 4
Synonyms

C2orf61, GSE
Links

HGNC:26850

NCBI Gene ID: 285051

neXtProt AC: NX_Q8N801

UniProt: Q8N801
Chr Location

2p21; chr2:47045538-47155308 (-) GRCh38

MGI Vertebrate Homology

Stpg4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STPG4
Gene Tree

Stpg4

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Phenotype Summary

6 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

5
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are viable and exhibit normal male fertility. Mice homozygous for a different null allele are viable, fertile and grossly normal but show abnormal active DNA demethylation of the paternal genome.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

16
UniProt

3
CCDS

CCDS50206.1

Ensembl

ENSMUSG00000036557 (Evidence)
NCBI Gene

75467

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036557	Ensembl Gene Model \| MGI Sequence Detail	38171	C57BL/6J	± kb
transcript	ENSMUST00000040609	Ensembl \| MGI Sequence Detail	847	Not Applicable
polypeptide	ENSMUSP00000044250	Ensembl \| MGI Sequence Detail	247	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000036934 protein STPG4

(term hierarchy)
InterPro Domains

IPR010736 Sperm-tail PG-rich repeat

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All nucleic 18

cDNA 18

Microarray probesets 10

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stpg4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149768	Chr17:87735201-87735206 (-)	-35 bp
Tssr149767	Chr17:87735160-87735169 (-)	4 bp
Tssr149766	Chr17:87735118-87735135 (-)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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