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Cfap276 Gene Detail
Summary
  • Symbol
    Cfap276
  • Name
    cilia and flagella associated protein 276
  • Synonyms
    1700013F07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922754
    NCBI Gene: 75504
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108444900-108452013 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 47.27 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922754
 protein coding gene Chr3:108441466-108452039 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027779
 protein coding gene Chr3:110092513-110104296 (+)
A/J MGP_AJ_G0027739
 protein coding gene Chr3:106598858-106610339 (+)
AKR/J MGP_AKRJ_G0027704
 protein coding gene Chr3:109189471-109199976 (+)
BALB/cJ MGP_BALBcJ_G0027751
 protein coding gene Chr3:106297386-106307729 (+)
C3H/HeJ MGP_C3HHeJ_G0027481
 protein coding gene Chr3:109550191-109561791 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028195
 protein coding gene Chr3:114194785-114207706 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025533
 protein coding gene Chr3:102735957-102746761 (+)
CAST/EiJ MGP_CASTEiJ_G0026937
 protein coding gene Chr3:108942925-108953853 (+)
CBA/J MGP_CBAJ_G0027456
 protein coding gene Chr3:118093026-118103622 (+)
DBA/2J MGP_DBA2J_G0027598
 protein coding gene Chr3:105777657-105788342 (+)
FVB/NJ MGP_FVBNJ_G0027566
 protein coding gene Chr3:103666615-103677101 (+)
LP/J MGP_LPJ_G0027705
 protein coding gene Chr3:111511465-111521342 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027596
 protein coding gene Chr3:124143766-124155822 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028250
 protein coding gene Chr3:108795700-108806204 (+)
PWK/PhJ MGP_PWKPhJ_G0026663
 protein coding gene Chr3:105529550-105540839 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026483
 protein coding gene Chr3:106933491-106950701 (+)
WSB/EiJ MGP_WSBEiJ_G0027017
 protein coding gene Chr3:109329398-109339858 (+)



Homology
more
  • Human Ortholog
    CFAP276, cilia and flagella associated protein 276
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFAP276, cilia and flagella associated protein 276
  • Synonyms
    C10orf194, C1orf194
  • Links
    NCBI Gene ID: 127003
    neXtProt AC: NX_Q5T5A4
    UniProt: Q5T5A4

  • Chr Location
    1p13.3; chr1:109105951-109113857 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cfap276 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A certain point mutation results in decreased body weight and motor and sensor neuropathy in the hind limbs. Male mice for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    18
  • cDNA Data
    20
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75504 NCBI Gene Model | MGI Sequence Detail 7114 C57BL/6J ±  kb
    transcript NM_029314 RefSeq | MGI Sequence Detail 592 Not Specified  
    polypeptide Q9DAD0 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:6885587
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:348435 Suzuki A, et al., Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. J Reprod Immunol. 2024;:104252
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory