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Trir Gene Detail
Summary
  • Symbol
    Trir
  • Name
    telomerase RNA component interacting RNase
  • Synonyms
    1110002H14Rik, 2310036O22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922833
    NCBI Gene: 68544
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85753452-85756915 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.49 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922833
 protein coding gene Chr8:85753440-85756920 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033888
 protein coding gene Chr8:85972725-85976165 (+)
A/J MGP_AJ_G0033871
 protein coding gene Chr8:82574456-82577904 (+)
AKR/J MGP_AKRJ_G0033797
 protein coding gene Chr8:85027998-85031438 (+)
BALB/cJ MGP_BALBcJ_G0033864
 protein coding gene Chr8:82710993-82714431 (+)
C3H/HeJ MGP_C3HHeJ_G0033574
 protein coding gene Chr8:85648227-85651675 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034384
 protein coding gene Chr8:89260633-89264083 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031325
 protein coding gene Chr8:76376815-76380237 (+)
CAST/EiJ MGP_CASTEiJ_G0032904
 protein coding gene Chr8:85079974-85083394 (+)
CBA/J MGP_CBAJ_G0033550
 protein coding gene Chr8:92283486-92286934 (+)
DBA/2J MGP_DBA2J_G0033703
 protein coding gene Chr8:82213916-82217362 (+)
FVB/NJ MGP_FVBNJ_G0033651
 protein coding gene Chr8:81172327-81175775 (+)
LP/J MGP_LPJ_G0033795
 protein coding gene Chr8:86074172-86077612 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033693
 protein coding gene Chr8:94853290-94856736 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034401
 protein coding gene Chr8:85016263-85019715 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0032444
 protein coding gene Chr8:83824927-83828360 (+)
WSB/EiJ MGP_WSBEiJ_G0033017
 protein coding gene Chr8:85443701-85447149 (+)



Homology
more
  • Human Ortholog
    TRIR, telomerase RNA component interacting RNase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIR, telomerase RNA component interacting RNase
  • Synonyms
    C19orf43, fSAP18, TERCIR
  • Links
    NCBI Gene ID: 79002
    neXtProt AC: NX_Q9BQ61
    UniProt: Q9BQ61

  • Chr Location
    19p13.13; chr19:12730640-12734684 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    8
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Trir
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    5 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    100
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041203 Ensembl Gene Model | MGI Sequence Detail 3464 C57BL/6J ±  kb
transcript ENSMUST00000047281 Ensembl | MGI Sequence Detail 902 Not Applicable  
polypeptide ENSMUSP00000044129 Ensembl | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 100
    cDNA 100

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915794, MGI:2142644, MGI:5898326
References
more
  • Summaries
    All 61
    Gene Ontology 4
    Phenotypes 35
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory