Chmp4b MGI Mouse Gene Detail - MGI:1922858 - charged multivesicular body protein 4B

Symbol

Chmp4b
Name

charged multivesicular body protein 4B
Synonyms

2010012F05Rik, chromatin modifying protein 4B, Snf7-2

Feature Type

protein coding gene
IDs

MGI:1922858
NCBI Gene: 75608
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr2:154498949-154536703 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 76.79 cM, cytoband H2
Mapping Data

3 experiments

SNPs within 2kb

931 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922858	protein coding gene	Chr2:154493625-154536705 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026723	protein coding gene	Chr2:159418869-159466222 (+)
A/J	MGP_AJ_G0026689	protein coding gene	Chr2:153054695-153099721 (+)
AKR/J	MGP_AKRJ_G0026660	protein coding gene	Chr2:157514615-157557274 (+)
BALB/cJ	MGP_BALBcJ_G0026698	protein coding gene	Chr2:153356025-153399551 (+)
C3H/HeJ	MGP_C3HHeJ_G0026441	protein coding gene	Chr2:157873142-157920539 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027147	protein coding gene	Chr2:164073377-164118736 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024517	protein coding gene	Chr2:146586190-146629268 (+)
CAST/EiJ	MGP_CASTEiJ_G0025902	protein coding gene	Chr2:158194360-158239094 (+)
CBA/J	MGP_CBAJ_G0026418	protein coding gene	Chr2:170043229-170105358 (+)
DBA/2J	MGP_DBA2J_G0026555	protein coding gene	Chr2:152274415-152320990 (+)
FVB/NJ	MGP_FVBNJ_G0026522	protein coding gene	Chr2:150671947-150715637 (+)
LP/J	MGP_LPJ_G0026660	protein coding gene	Chr2:159535446-159584966 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026543	protein coding gene	Chr2:174085325-174136281 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027203	protein coding gene	Chr2:157387266-157440465 (+)
PWK/PhJ	MGP_PWKPhJ_G0025636	protein coding gene	Chr2:151764025-151812335 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025439	protein coding gene	Chr2:156348056-156395101 (+)
WSB/EiJ	MGP_WSBEiJ_G0025972	protein coding gene	Chr2:158319594-158364514 (+)

Human Ortholog

CHMP4B, charged multivesicular body protein 4B

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHMP4B, charged multivesicular body protein 4B
Synonyms

C20orf178, CHMP4A, CTPP3, CTRCT31, dJ553F4.4, Shax1, SNF7, SNF7-2, Vps32-2, VPS32B
Links

HGNC:16171

NCBI Gene ID: 128866

neXtProt AC: NX_Q9H444

UniProt: Q9H444
Chr Location

20q11.22; chr20:33811348-33854366 (+) GRCh38

MGI Vertebrate Homology

Chmp4b stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: CHMP4B
Gene Tree

Chmp4b

Diseases

1 with human CHMP4B associations

				Human Disease	Mouse Models
				cataract 31 multiple types IDs cataract 31 multiple types DOID:0110265 ICD10CM:Q12.0 OMIM:605387

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Endonuclease-mediated

3
Gene trapped

34
Targeted

4
Find Mice (IMSR)

41 strains or lines available

Mice homozygous for a gene trap insertion die between E7.5 and E8.5.

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All GO Annotations

99
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

786
Tissues

63
cDNA Data

115
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chmp4b

ZFIN chmp4bb

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All Sequences

43
RefSeq

2
UniProt

1
CCDS

CCDS16938.1

Ensembl

ENSMUSG00000038467 (Evidence)
NCBI Gene

75608

			Length	Strain/Species	Flank
genomic	75608	NCBI Gene Model \| MGI Sequence Detail	37755	C57BL/6J	± kb
transcript	NM_029362	RefSeq \| MGI Sequence Detail	1603	C57BL/6
polypeptide	Q9D8B3	UniProt \| EBI \| MGI Sequence Detail	224	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005437 charged multivesicular body protein 4b

(term hierarchy)
InterPro Domains

IPR005024 Snf7 family

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All nucleic 119

cDNA 115

Primer pair 4

Microarray probesets 6

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MGI:2139458

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 13

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:341334 Zhou Y, et al., Charged multivesicular body protein 4b forms complexes with gap junction proteins during lens fiber cell differentiation. FASEB J. 2023 Apr;37(4):e22801

TSS for Chmp4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21032	Chr2:154498805-154498814 (+)	-139 bp
Tssr21033	Chr2:154498833-154498844 (+)	-110 bp
Tssr21034	Chr2:154498879-154499028 (+)	5 bp
Tssr21035	Chr2:154499033-154499054 (+)	95 bp
Tssr21036	Chr2:154499057-154499081 (+)	120 bp
Tssr21037	Chr2:154499085-154499100 (+)	144 bp
Tssr21038	Chr2:154499134-154499157 (+)	197 bp
Tssr21039	Chr2:154506508-154506534 (+)	7,572 bp
Tssr21040	Chr2:154514349-154514354 (+)	15,403 bp
Tssr21041	Chr2:154531519-154531542 (+)	32,582 bp
Tssr21042	Chr2:154531568-154531593 (+)	32,632 bp
Tssr21043	Chr2:154533185-154533208 (+)	34,248 bp
Tssr21044	Chr2:154536124-154536146 (+)	37,186 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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