Psmg2 MGI Mouse Gene Detail - MGI:1922901 - proteasome (prosome, macropain) assembly chaperone 2

Symbol

Psmg2
Name

proteasome (prosome, macropain) assembly chaperone 2
Synonyms

1700017I17Rik, Clast3, Tnfsf5ip1

Feature Type

protein coding gene
IDs

MGI:1922901
NCBI Gene: 107047
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:67774669-67787232 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 40.05 cM
Mapping Data

2 experiments

SNPs within 2kb

549 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922901	protein coding gene	Chr18:67774657-67787251 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024528	protein coding gene	Chr18:67949131-67961678 (+)
A/J	MGP_AJ_G0024495	protein coding gene	Chr18:64979953-64992674 (+)
AKR/J	MGP_AKRJ_G0024466	protein coding gene	Chr18:66886805-66899351 (+)
BALB/cJ	MGP_BALBcJ_G0024495	protein coding gene	Chr18:65146667-65159205 (+)
C3H/HeJ	MGP_C3HHeJ_G0024263	protein coding gene	Chr18:67040533-67053090 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024941	protein coding gene	Chr18:69728347-69740903 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022372	protein coding gene	Chr18:64356348-64368902 (+)
CAST/EiJ	MGP_CASTEiJ_G0023735	protein coding gene	Chr18:67040954-67055453 (+)
CBA/J	MGP_CBAJ_G0024232	protein coding gene	Chr18:72143374-72155926 (+)
DBA/2J	MGP_DBA2J_G0024362	protein coding gene	Chr18:64628770-64641324 (+)
FVB/NJ	MGP_FVBNJ_G0024328	protein coding gene	Chr18:64000335-64012999 (+)
LP/J	MGP_LPJ_G0024446	protein coding gene	Chr18:67809662-67823755 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024358	protein coding gene	Chr18:73412223-73426266 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024989	protein coding gene	Chr18:67050835-67064852 (+)
PWK/PhJ	MGP_PWKPhJ_G0023480	protein coding gene	Chr18:64914562-64927503 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023284	protein coding gene	Chr18:67218276-67231040 (+)
WSB/EiJ	MGP_WSBEiJ_G0023799	protein coding gene	Chr18:66960225-66975563 (+)

Human Ortholog

PSMG2, proteasome assembly chaperone 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMG2, proteasome assembly chaperone 2
Synonyms

CLAST3, HCCA3, HsT1707, MDS003, PAC2, PRAAS4, TNFSF5IP1
Links

HGNC:24929

NCBI Gene ID: 56984

neXtProt AC: NX_Q969U7

UniProt: Q969U7
Chr Location

18p11.21; chr18:12658043-12728945 (+) GRCh38

MGI Vertebrate Homology

Psmg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PSMG2
Protein SuperFamily

UCP010044
Gene Tree

Psmg2

Diseases

1 with human PSMG2 associations

				Human Disease	Mouse Models
				proteosome-associated autoinflammatory syndrome 4 IDs proteosome-associated autoinflammatory syndrome 4 DOID:0060915 OMIM:619183

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

14
Gene trapped

11
Targeted

3
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

76
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase psmg2

ZFIN psmg2

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All Sequences

42
RefSeq

4
UniProt

1
CCDS

CCDS29324.1, CCDS89268.1

Ensembl

ENSMUSG00000024537 (Evidence)
NCBI Gene

107047

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024537	Ensembl Gene Model \| MGI Sequence Detail	12564	C57BL/6J	± kb
transcript	ENSMUST00000025418	Ensembl \| MGI Sequence Detail	1059	Not Applicable
polypeptide	ENSMUSP00000025418	Ensembl \| MGI Sequence Detail	264	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013398 proteasome assembly chaperone 2

(term hierarchy)
InterPro Domains

IPR019151 Proteasome assembly chaperone 2

IPR016562 Proteasome assembly chaperone 2, eukaryotic

IPR038389 Proteasome assembly chaperone 2 superfamily
GlyGen

Q9EST4 1 site, 1 O-linked glycan (1 site)

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All nucleic 76

cDNA 76

Microarray probesets 4

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MGI:2147369

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26

TSS for Psmg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151746	Chr18:67774632-67774656 (+)	-25 bp
Tssr151747	Chr18:67774659-67774700 (+)	11 bp
Tssr151748	Chr18:67774701-67774712 (+)	38 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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