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Mfsd6 Gene Detail
Summary
  • Symbol
    Mfsd6
  • Name
    major facilitator superfamily domain containing 6
  • Synonyms
    2210010L05Rik, 9630025I22Rik, MMR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922925
    NCBI Gene: 98682
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:52695463-52766495 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 26.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922925
 protein coding gene Chr1:52695445-52766621 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016010
 protein coding gene Chr1:52175979-52247637 (-)
A/J MGP_AJ_G0015992
 protein coding gene Chr1:50427164-50493883 (-)
AKR/J MGP_AKRJ_G0015948
 protein coding gene Chr1:51496743-51575140 (-)
BALB/cJ MGP_BALBcJ_G0015949
 protein coding gene Chr1:50247366-50319077 (-)
C3H/HeJ MGP_C3HHeJ_G0015781
 protein coding gene Chr1:51893825-51962680 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016400
 protein coding gene Chr1:54376581-54451055 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014124
 protein coding gene Chr1:41379906-41445128 (+)
CAST/EiJ MGP_CASTEiJ_G0015362
 protein coding gene Chr1:51391627-51457464 (-)
CBA/J MGP_CBAJ_G0015752
 protein coding gene Chr1:55808949-55879091 (-)
DBA/2J MGP_DBA2J_G0015853
 protein coding gene Chr1:49698496-49768649 (-)
FVB/NJ MGP_FVBNJ_G0015855
 protein coding gene Chr1:49153112-49223678 (-)
LP/J MGP_LPJ_G0015924
 protein coding gene Chr1:52658057-52723989 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015875
 protein coding gene Chr1:58862278-58939072 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016448
 protein coding gene Chr1:51625059-51702120 (-)
PWK/PhJ MGP_PWKPhJ_G0015148
 protein coding gene Chr1:49550836-49620854 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014928
 protein coding gene Chr1:51281373-51353995 (-)
WSB/EiJ MGP_WSBEiJ_G0015425
 protein coding gene Chr1:51440604-51511995 (-)



Homology
more
  • Human Ortholog
    MFSD6, major facilitator superfamily domain containing 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MFSD6, major facilitator superfamily domain containing 6
  • Synonyms
    hMMR2, MMR2
  • Links
    NCBI Gene ID: 54842
    neXtProt AC: NX_Q6ZSS7
    UniProt: Q6ZSS7

  • Chr Location
    2q32.2; chr2:190407576-190509205 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    11
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 98682 NCBI Gene Model | MGI Sequence Detail 71033 C57BL/6J ±  kb
transcript NM_001357464 RefSeq | MGI Sequence Detail 4813 C57BL/6  
polypeptide Q8CBH5 UniProt | EBI | MGI Sequence Detail 775 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010909 major facilitator superfamily domain-containing protein 6
    (term hierarchy)
  • InterPro Domains
    IPR024989 Major facilitator superfamily associated domain
    IPR051717 Major facilitator superfamily MFSD6
    IPR036259 MFS transporter superfamily
  • GlyGen
    Q8CBH5 6 sites, 6 N-linked glycans (6 sites)
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2138326, MGI:2138577, MGI:2443224
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory