Brsk2 MGI Mouse Gene Detail - MGI:1923020 - BR serine/threonine kinase 2

Symbol

Brsk2
Name

BR serine/threonine kinase 2
Synonyms

4833424K13Rik, SAD-A

Feature Type

protein coding gene
IDs

MGI:1923020
NCBI Gene: 75770
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:141503488-141557981 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 87.43 cM, cytoband F5
Mapping Data

2 experiments

SNPs within 2kb

1015 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923020	protein coding gene	Chr7:141503488-141557984 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033243	protein coding gene	Chr7:147146836-147209093 (+)
A/J	MGP_AJ_G0033224	protein coding gene	Chr7:142929255-142985218 (+)
AKR/J	MGP_AKRJ_G0033158	protein coding gene	Chr7:146913210-146974794 (+)
BALB/cJ	MGP_BALBcJ_G0033226	protein coding gene	Chr7:142664201-142718634 (+)
C3H/HeJ	MGP_C3HHeJ_G0032940	protein coding gene	Chr7:146642791-146698028 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033738	protein coding gene	Chr7:152512663-152571185 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030711	protein coding gene	Chr7:144122479-144174764 (+)
CAST/EiJ	MGP_CASTEiJ_G0032271	protein coding gene	Chr7:138966523-139022180 (+)
CBA/J	MGP_CBAJ_G0032913	protein coding gene	Chr7:157676616-157734886 (+)
DBA/2J	MGP_DBA2J_G0033065	protein coding gene	Chr7:140865609-140921611 (+)
FVB/NJ	MGP_FVBNJ_G0033017	protein coding gene	Chr7:140785819-140840673 (+)
LP/J	MGP_LPJ_G0033160	protein coding gene	Chr7:148644167-148701848 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033051	protein coding gene	Chr7:158307039-158366371 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033756	protein coding gene	Chr7:145858361-145916666 (+)
PWK/PhJ	MGP_PWKPhJ_G0031975	protein coding gene	Chr7:134164063-134215241 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031821	protein coding gene	Chr7:132681131-132733579 (+)
WSB/EiJ	MGP_WSBEiJ_G0032381	protein coding gene	Chr7:146823041-146888960 (+)

Human Ortholog

BRSK2, BR serine/threonine kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BRSK2, BR serine/threonine kinase 2
Synonyms

C11orf7, PEN11B, SAD1, SAD-A, SADA, STK29
Links

HGNC:11405

NCBI Gene ID: 9024

neXtProt AC: NX_Q8IWQ3

UniProt: Q8IWQ3
Chr Location

11p15.5; chr11:1389899-1462689 (+) GRCh38

MGI Vertebrate Homology

Brsk2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BRSK2
Gene Tree

Brsk2

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
11 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Radiation induced

1
Targeted

9
Genomic Mutations

1 involving Brsk2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available

Homozygous mutant mice are healthy and fertile. Mice homozygous for a condition allele activated in sensory and motor neurons exhibit partial neonatal lethality, hypokinesis, absnece of gastric milk and abnormal type Ia proprioceptive sensory neuron projections

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All GO Annotations

78
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

15
cDNA Data

6
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase brsk2

ZFIN brsk2a, brsk2b

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All Sequences

83
RefSeq

8
UniProt

11
CCDS

CCDS22021.1, CCDS22022.1, CCDS22023.1

Ensembl

ENSMUSG00000053046 (Evidence)
NCBI Gene

75770

			Length	Strain/Species	Flank
genomic	75770	NCBI Gene Model \| MGI Sequence Detail	54494	C57BL/6J	± kb
transcript	NM_001009930	RefSeq \| MGI Sequence Detail	4507	C57BL/6
polypeptide	Q69Z98	UniProt \| EBI \| MGI Sequence Detail	735	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000004824 serine/threonine-protein kinase BRSK2

(term hierarchy)
PDB

4YNZ, 4YOM
EC

2.7.11.1, 2.7.11.26
InterPro Domains

IPR048622 BRSK1/2-like, UBA domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 7

cDNA 7

Microarray probesets 3

Summaries

All 54

Developmental Gene Expression 8

Gene Ontology 14

Phenotypes 16
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:330942 Chu Q, et al., STK11 is required for the normal program of ciliated cell differentiation in airways. Cell Discov. 2019;5:36

TSS for Brsk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70113	Chr7:141503384-141503393 (+)	-99 bp
Tssr70114	Chr7:141503411-141503424 (+)	-70 bp
Tssr70115	Chr7:141503425-141503534 (+)	-8 bp
Tssr70116	Chr7:141503589-141503605 (+)	109 bp
Tssr70117	Chr7:141503612-141503635 (+)	136 bp
Tssr70118	Chr7:141503719-141503732 (+)	238 bp
Tssr2452	Chr7:141551182-141551184 (+)	47,695 bp
Tssr70119	Chr7:141551218-141551228 (+)	47,735 bp
Tssr70120	Chr7:141551229-141551240 (+)	47,747 bp
Tssr2453	Chr7:141551273-141551278 (+)	47,788 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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