Ckap5 MGI Mouse Gene Detail - MGI:1923036 - cytoskeleton associated protein 5

Symbol

Ckap5
Name

cytoskeleton associated protein 5
Synonyms

3110043H24Rik, 4930432B04Rik, D730027C18Rik, mKIAA0097

Feature Type

protein coding gene
IDs

MGI:1923036
NCBI Gene: 75786
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:91357107-91451009 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.63 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

1655 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923036	protein coding gene	Chr2:91357092-91451024 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026151	protein coding gene	Chr2:92872270-92969224 (+)
A/J	MGP_AJ_G0026112	protein coding gene	Chr2:89140573-89239846 (+)
AKR/J	MGP_AKRJ_G0026093	protein coding gene	Chr2:91611799-91708135 (+)
BALB/cJ	MGP_BALBcJ_G0026121	protein coding gene	Chr2:89331561-89424320 (+)
C3H/HeJ	MGP_C3HHeJ_G0025872	protein coding gene	Chr2:91895209-91990449 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026572	protein coding gene	Chr2:96121535-96222417 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023963	protein coding gene	Chr2:85644113-85737129 (+)
CAST/EiJ	MGP_CASTEiJ_G0025337	protein coding gene	Chr2:92438819-92537511 (+)
CBA/J	MGP_CBAJ_G0025850	protein coding gene	Chr2:99427054-99527130 (+)
DBA/2J	MGP_DBA2J_G0025986	protein coding gene	Chr2:88744609-88842514 (+)
FVB/NJ	MGP_FVBNJ_G0025949	protein coding gene	Chr2:87848643-87940387 (+)
LP/J	MGP_LPJ_G0026090	protein coding gene	Chr2:93072511-93185612 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025975	protein coding gene	Chr2:102439348-102544467 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026626	protein coding gene	Chr2:91683441-91780861 (+)
PWK/PhJ	MGP_PWKPhJ_G0025072	protein coding gene	Chr2:88479937-88576258 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024873	protein coding gene	Chr2:91256492-91361539 (+)
WSB/EiJ	MGP_WSBEiJ_G0025404	protein coding gene	Chr2:92288143-92381749 (+)

Human Ortholog

CKAP5, cytoskeleton associated protein 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CKAP5, cytoskeleton associated protein 5
Synonyms

ch-TOG, CHTOG, MSPS, TOG, TOGp
Links

HGNC:28959

NCBI Gene ID: 9793

neXtProt AC: NX_Q14008

UniProt: Q14008
Chr Location

11p11.2; chr11:46743048-46846308 (-) GRCh38

MGI Vertebrate Homology

Ckap5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CKAP5
Gene Tree

Ckap5

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Phenotype Summary

20 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

38
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

4 involving Ckap5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

95 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic disruption of this gene exhibit decreased body size and cleft palate while a targeted null allele causes embryonic lethality in homozygotes and heterozygotes have decreased body temperature, abnormal retina outer nuclear layer, and abnormal embryo size

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All GO Annotations

52
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

926
Tissues

86
cDNA Data

450
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ckap5

ZFIN ckap5

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All Sequences

77
RefSeq

16
UniProt

8
CCDS

CCDS16433.1, CCDS50640.1

Ensembl

ENSMUSG00000040549 (Evidence)
NCBI Gene

75786

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040549	Ensembl Gene Model \| MGI Sequence Detail	93903	C57BL/6J	± kb
transcript	ENSMUST00000111338	Ensembl \| MGI Sequence Detail	6665	Not Applicable
polypeptide	ENSMUSP00000106970	Ensembl \| MGI Sequence Detail	2032	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005512 cytoskeleton-associated protein 5

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR024395 CLASP N-terminal domain

IPR000357 HEAT repeat

IPR021133 HEAT, type 2

IPR034085 TOG domain

IPR045110 XMAP215

IPR048491 XMAP215/Dis1/CLASP, TOG domain
GlyGen

A2AGT5 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 452

cDNA 451

Primer pair 1

Microarray probesets 4

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MGI:1920470, MGI:2139548, MGI:2441987

Summaries

All 58

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 22
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ckap5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18900	Chr2:91357101-91357108 (+)	-2 bp
Tssr18901	Chr2:91357115-91357173 (+)	37 bp
Tssr565	Chr2:91357178-91357185 (+)	75 bp
Tssr18902	Chr2:91357186-91357197 (+)	85 bp
Tssr18903	Chr2:91357288-91357332 (+)	203 bp
Tssr18904	Chr2:91368159-91368180 (+)	11,063 bp
Tssr18905	Chr2:91376650-91376674 (+)	19,555 bp
Tssr18906	Chr2:91411492-91411511 (+)	54,395 bp
Tssr18907	Chr2:91416471-91416482 (+)	59,370 bp
Tssr18908	Chr2:91416508-91416520 (+)	59,407 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24