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Saxo1 Gene Detail
Summary
  • Symbol
    Saxo1
  • Name
    stabilizer of axonemal microtubules 1
  • Synonyms
    4930500O09Rik, Fam154a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923061
    NCBI Gene: 75811
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:86362878-86476565 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 40.69 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3090 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923061
 protein coding gene Chr4:86362662-86476565 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028410
 protein coding gene Chr4:86208904-86320960 (-)
A/J MGP_AJ_G0028371
 protein coding gene Chr4:83177528-83313636 (-)
AKR/J MGP_AKRJ_G0028320
 protein coding gene Chr4:85299407-85407065 (-)
BALB/cJ MGP_BALBcJ_G0028391
 protein coding gene Chr4:83397034-83496915 (-)
C3H/HeJ MGP_C3HHeJ_G0028106
 protein coding gene Chr4:85954185-86061711 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028830
 protein coding gene Chr4:89475206-89588981 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026130
 protein coding gene Chr4:79307247-79407366 (-)
CAST/EiJ MGP_CASTEiJ_G0027547
 protein coding gene Chr4:83851750-83962671 (-)
CBA/J MGP_CBAJ_G0028075
 protein coding gene Chr4:92256482-92379571 (-)
DBA/2J MGP_DBA2J_G0028224
 protein coding gene Chr4:82949515-83057428 (-)
FVB/NJ MGP_FVBNJ_G0028190
 protein coding gene Chr4:81937394-82045460 (-)
LP/J MGP_LPJ_G0028324
 protein coding gene Chr4:86537788-86656045 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028219
 protein coding gene Chr4:97316413-97432884 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028867
 protein coding gene Chr4:85376239-85486736 (-)
PWK/PhJ MGP_PWKPhJ_G0027270
 protein coding gene Chr4:81293331-81402502 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027095
 protein coding gene Chr4:82931499-83037374 (-)
WSB/EiJ MGP_WSBEiJ_G0027623
 protein coding gene Chr4:85563227-85670865 (-)



Homology
more
  • Human Ortholog
    SAXO1, stabilizer of axonemal microtubules 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAXO1, stabilizer of axonemal microtubules 1
  • Synonyms
    C9orf138, FAM154A
  • Links
    NCBI Gene ID: 158297
    neXtProt AC: NX_Q8IYX7
    UniProt: Q8IYX7

  • Chr Location
    9p22.1; chr9:18858906-19049358 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028492 Ensembl Gene Model | MGI Sequence Detail 113688 C57BL/6J ±  kb
    transcript ENSMUST00000030216 Ensembl | MGI Sequence Detail 1892 Not Applicable  
    polypeptide ENSMUSP00000030216 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR033336 Stabilizer of axonemal microtubules 1/2
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 2
    References
    more
    • Summaries
      All 31
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory