Tasp1 MGI Mouse Gene Detail - MGI:1923062 - taspase, threonine aspartase 1

Symbol

Tasp1
Name

taspase, threonine aspartase 1
Synonyms

4930485D02Rik

Feature Type

protein coding gene
IDs

MGI:1923062
NCBI Gene: 75812
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:139675400-139908725 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 69.20 cM
Mapping Data

2 experiments

SNPs within 2kb

5593 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923062	protein coding gene	Chr2:139675399-139908767 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026566	protein coding gene	Chr2:143743495-143988820 (-)
A/J	MGP_AJ_G0026530	protein coding gene	Chr2:137937285-138163500 (-)
AKR/J	MGP_AKRJ_G0026504	protein coding gene	Chr2:141875980-142113295 (-)
BALB/cJ	MGP_BALBcJ_G0026542	protein coding gene	Chr2:138322279-138561083 (-)
C3H/HeJ	MGP_C3HHeJ_G0026285	protein coding gene	Chr2:142381791-142624496 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026987	protein coding gene	Chr2:148053546-148304282 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024364	protein coding gene	Chr2:132256982-132479301 (-)
CAST/EiJ	MGP_CASTEiJ_G0025746	protein coding gene	Chr2:142687537-142934910 (-)
CBA/J	MGP_CBAJ_G0026265	protein coding gene	Chr2:153477426-153745531 (-)
DBA/2J	MGP_DBA2J_G0026399	protein coding gene	Chr2:137262971-137490688 (-)
FVB/NJ	MGP_FVBNJ_G0026363	protein coding gene	Chr2:135823365-136058922 (-)
LP/J	MGP_LPJ_G0026503	protein coding gene	Chr2:143893592-144139381 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026383	protein coding gene	Chr2:157483898-157747350 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027042	protein coding gene	Chr2:141849920-142086031 (-)
PWK/PhJ	MGP_PWKPhJ_G0025482	protein coding gene	Chr2:136845158-137076297 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025284	protein coding gene	Chr2:140913513-141177615 (-)
WSB/EiJ	MGP_WSBEiJ_G0025820	protein coding gene	Chr2:142820287-143065055 (-)

Human Ortholog

TASP1, taspase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TASP1, taspase 1
Synonyms

C20orf13, dJ585I14.2, SULEHS
Links

HGNC:15859

NCBI Gene ID: 55617

neXtProt AC: NX_Q9H6P5

UniProt: Q9H6P5
Chr Location

20p12.1; chr20:13104772-13638932 (-) GRCh38

MGI Vertebrate Homology

Tasp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TASP1
Gene Tree

Tasp1

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Phenotype Summary

29 phenotypes from 2 alleles in 4 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Gene trapped

9
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Tasp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display prenatal and early postnatal lethality, reduced body size, impaired suckling behavior, homeotic transformations of the axial skeleton, and cell cycle defects.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

4
cDNA Data

31
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tasp1

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All Sequences

88
RefSeq

45
UniProt

2
CCDS

CCDS16802.1, CCDS50731.1

Ensembl

ENSMUSG00000039033 (Evidence)
NCBI Gene

75812

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039033	Ensembl Gene Model \| MGI Sequence Detail	233326	C57BL/6J	± kb
transcript	ENSMUST00000110079	Ensembl \| MGI Sequence Detail	2258	Not Applicable
polypeptide	ENSMUSP00000105706	Ensembl \| MGI Sequence Detail	420	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016088 threonine aspartase 1

(term hierarchy)
EC

3.4.25.-
InterPro Domains

IPR029055 Nucleophile aminohydrolases, N-terminal

IPR000246 Peptidase T2, asparaginase 2

IPR037464 Threonine aspartase 1

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All nucleic 32

cDNA 31

Other 1

Microarray probesets 3

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MGI:2139420

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:309739 Niizuma H, et al., Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA. JCI Insight. 2021 Aug 9;6(15)

TSS for Tasp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26543	Chr2:139908581-139908716 (-)	76 bp
Tssr26542	Chr2:139907745-139907767 (-)	969 bp
Tssr26541	Chr2:139902135-139902142 (-)	6,586 bp
Tssr26540	Chr2:139884092-139884112 (-)	24,623 bp
Tssr26539	Chr2:139884059-139884090 (-)	24,650 bp
Tssr26538	Chr2:139884042-139884052 (-)	24,678 bp
Tssr26537	Chr2:139861378-139861384 (-)	47,344 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24