Rnf139 MGI Mouse Gene Detail - MGI:1923091

Symbol

Rnf139
Name

ring finger protein 139
Synonyms

4930555P18Rik

Feature Type

protein coding gene
IDs

MGI:1923091
NCBI Gene: 75841
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:58760975-58774239 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 25.09 cM
Mapping Data

1 experiment

SNPs within 2kb

260 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923091	protein coding gene	Chr15:58760975-58778906 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021878	protein coding gene	Chr15:58096472-58109641 (+)
A/J	MGP_AJ_G0021838	protein coding gene	Chr15:55824718-55838173 (+)
AKR/J	MGP_AKRJ_G0021819	protein coding gene	Chr15:57361073-57374234 (+)
BALB/cJ	MGP_BALBcJ_G0021845	protein coding gene	Chr15:56042703-56055864 (+)
C3H/HeJ	MGP_C3HHeJ_G0021619	protein coding gene	Chr15:57497075-57510236 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022284	protein coding gene	Chr15:60339832-60353953 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019821	protein coding gene	Chr15:52914770-52930043 (+)
CAST/EiJ	MGP_CASTEiJ_G0021136	protein coding gene	Chr15:58150453-58165029 (+)
CBA/J	MGP_CBAJ_G0021588	protein coding gene	Chr15:62436165-62457029 (+)
DBA/2J	MGP_DBA2J_G0021712	protein coding gene	Chr15:55737966-55751090 (+)
FVB/NJ	MGP_FVBNJ_G0021690	protein coding gene	Chr15:54781889-54795071 (+)
LP/J	MGP_LPJ_G0021782	protein coding gene	Chr15:57951933-57965422 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021714	protein coding gene	Chr15:67497513-67510674 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022307	protein coding gene	Chr15:57770156-57783317 (+)
PWK/PhJ	MGP_PWKPhJ_G0020881	protein coding gene	Chr15:55743142-55757749 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020718	protein coding gene	Chr15:57570257-57584491 (+)
WSB/EiJ	MGP_WSBEiJ_G0021191	protein coding gene	Chr15:57770694-57784907 (+)

Human Ortholog

RNF139, ring finger protein 139

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF139, ring finger protein 139
Synonyms

HRCA1, RCA1, TRC8
Links

HGNC:17023

NCBI Gene ID: 11236

neXtProt AC: NX_Q8WU17

UniProt: Q8WU17
Chr Location

8q24.13; chr8:124474880-124488618 (+) GRCh38

MGI Vertebrate Homology

Rnf139 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF139
Gene Tree

Rnf139

Diseases

1 with human RNF139 associations

				Human Disease	Mouse Models
				renal cell carcinoma IDs renal cell carcinoma DOID:4450 EFO:0000681 MESH:D002292 NCI:C9385 OMIM:300854 ORDO:217071 UMLS_CUI:C0007134

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

3
Radiation induced

2
Targeted

1
Genomic Mutations

5 involving Rnf139
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased diet-induced liver apoptosis, inflammation and fibrosis.

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

30
cDNA Data

8
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf139

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All Sequences

38
RefSeq

4
UniProt

2
CCDS

CCDS27494.1

Ensembl

ENSMUSG00000037075 (Evidence)
NCBI Gene

75841

			Length	Strain/Species	Flank
genomic	75841	NCBI Gene Model \| MGI Sequence Detail	13265	C57BL/6J	± kb
transcript	NM_175226	RefSeq \| MGI Sequence Detail	4348	C57BL/6
polypeptide	Q7TMV1	UniProt \| EBI \| MGI Sequence Detail	668	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014085 E3 ubiquitin-protein ligase RNF139

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR050731 HRD1 family E3 ubiquitin-protein ligases

IPR025754 TRC8-like, N-terminal domain

IPR011016 Zinc finger, RING-CH-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 8

cDNA 8

Microarray probesets 4

Summaries

All 52

Developmental Gene Expression 3

Diseases 1

Gene Ontology 7

Phenotypes 26
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Rnf139:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131350	Chr15:58760769-58760818 (+)	-181 bp
Tssr131351	Chr15:58760822-58760859 (+)	-134 bp
Tssr131352	Chr15:58760863-58760877 (+)	-105 bp
Tssr131353	Chr15:58760920-58761000 (+)	-15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24