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Samd7 Gene Detail
Summary
  • Symbol
    Samd7
  • Name
    sterile alpha motif domain containing 7
  • Synonyms
    4930597A01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923203
    NCBI Gene: 75953
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:30800481-30821323 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 14.27 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    739 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923203
 protein coding gene Chr3:30800442-30821323 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027126
 protein coding gene Chr3:28243988-28268563 (+)
A/J MGP_AJ_G0027086
 protein coding gene Chr3:27878916-27899894 (+)
AKR/J MGP_AKRJ_G0027055
 protein coding gene Chr3:28309429-28330187 (+)
BALB/cJ MGP_BALBcJ_G0027098
 protein coding gene Chr3:27571286-27592712 (+)
C3H/HeJ MGP_C3HHeJ_G0026840
 protein coding gene Chr3:28327650-28348378 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027544
 protein coding gene Chr3:29751797-29776420 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024905
 protein coding gene Chr3:25791320-25813195 (+)
CAST/EiJ MGP_CASTEiJ_G0026294
 protein coding gene Chr3:28242260-28269703 (+)
CBA/J MGP_CBAJ_G0026818
 protein coding gene Chr3:30504963-30527320 (+)
DBA/2J MGP_DBA2J_G0026952
 protein coding gene Chr3:27431889-27452461 (+)
FVB/NJ MGP_FVBNJ_G0026920
 protein coding gene Chr3:26878388-26900189 (+)
LP/J MGP_LPJ_G0027063
 protein coding gene Chr3:28942994-28965446 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026940
 protein coding gene Chr3:33088555-33110605 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027603
 protein coding gene Chr3:28044385-28070731 (+)
PWK/PhJ MGP_PWKPhJ_G0026027
 protein coding gene Chr3:26946232-26968115 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025839
 protein coding gene Chr3:27577816-27598653 (+)
WSB/EiJ MGP_WSBEiJ_G0026368
 protein coding gene Chr3:28147539-28168292 (+)



Homology
more
  • Human Ortholog
    SAMD7, sterile alpha motif domain containing 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAMD7, sterile alpha motif domain containing 7
  • Synonyms
    MDCD
  • Links
    NCBI Gene ID: 344658
    neXtProt AC: NX_Q7Z3H4
    UniProt: Q7Z3H4

  • Chr Location
    3q26.2; chr3:169911572-169939175 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SAMD7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout reduces the sensitivity of the retinal rods to low-to-moderate flash luminescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    21
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75953 NCBI Gene Model | MGI Sequence Detail 20843 C57BL/6J ±  kb
    transcript NM_029489 RefSeq | MGI Sequence Detail 3152 C57BL/6  
    polypeptide Q8C8Y5 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000029744 sterile alpha motif domain-containing protein 7
      (term hierarchy)
    • InterPro Domains
      IPR050548 Polycomb group and chromatin remodeling factors
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory