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Srrm2 Gene Detail
Summary
  • Symbol
    Srrm2
  • Name
    serine/arginine repetitive matrix 2
  • Synonyms
    5033413A03Rik, mKIAA0324, SRm300
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923206
    NCBI Gene: 75956
  • Alliance
    gene page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24009506-24043715 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    590 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923206
 protein coding gene Chr17:24009501-24043715 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023272
 protein coding gene Chr17:22709260-22749904 (+)
A/J MGP_AJ_G0023232
 protein coding gene Chr17:22053439-22095787 (+)
AKR/J MGP_AKRJ_G0023202
 protein coding gene Chr17:22133239-22175346 (+)
BALB/cJ MGP_BALBcJ_G0023237
 protein coding gene Chr17:22270074-22304914 (+)
C3H/HeJ MGP_C3HHeJ_G0022997
 protein coding gene Chr17:22501030-22545093 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023680
 protein coding gene Chr17:23699951-23735393 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021161
 protein coding gene Chr17:19616883-19651553 (+)
CAST/EiJ MGP_CASTEiJ_G0022503
 protein coding gene Chr17:22327554-22367686 (+)
CBA/J MGP_CBAJ_G0022973
 protein coding gene Chr17:24512397-24558107 (+)
DBA/2J MGP_DBA2J_G0023105
 protein coding gene Chr17:21683317-21723520 (+)
FVB/NJ MGP_FVBNJ_G0023072
 protein coding gene Chr17:21409118-21444484 (+)
LP/J MGP_LPJ_G0023179
 protein coding gene Chr17:22973831-23017219 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023091
 protein coding gene Chr17:24266231-24302778 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023719
 protein coding gene Chr17:22431775-22470178 (+)
PWK/PhJ MGP_PWKPhJ_G0022251
 protein coding gene Chr17:20470742-20506520 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022071
 protein coding gene Chr17:20450542-20483409 (+)
WSB/EiJ MGP_WSBEiJ_G0022566
 protein coding gene Chr17:22483099-22520966 (+)



Homology
more
  • Human Ortholog
    SRRM2, serine/arginine repetitive matrix 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRRM2, serine/arginine repetitive matrix 2
  • Synonyms
    300-KD, Cwc21, CWF21, HSPC075, MRD72, SRL300, SRm300
  • Links
    NCBI Gene ID: 23524
    neXtProt AC: NX_Q9UQ35
    UniProt: Q9UQ35

  • Chr Location
    16p13.3; chr16:2752626-2772538 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SRRM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039218 Ensembl Gene Model | MGI Sequence Detail 34210 C57BL/6J ±  kb
transcript ENSMUST00000190686 Ensembl | MGI Sequence Detail 8864 Not Applicable  
polypeptide ENSMUSP00000139842 Ensembl | MGI Sequence Detail 2703 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000015639 serine/arginine repetitive matrix protein 2
    (term hierarchy)
  • InterPro Domains
    IPR013170 mRNA splicing factor Cwf21 domain
    IPR051372 Pre-mRNA-splicing factor CWC21
    IPR052109 Serine/Arginine Repetitive Matrix Domain-Containing Protein
    IPR047490 Serine/arginine repetitive matrix protein 2, cwf21 domain
    IPR024945 Spt5 C-terminal domain
  • GlyGen
    Q8BTI8 13 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (11 sites)
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 7
Other
Accession IDs
less
MGI:2146764
References
more
  • Summaries
    All 40
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:70954 Blencowe BJ, et al., A coactivator of pre-mRNA splicing. Genes Dev. 1998 Apr 1;12(7):996-1009
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory