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Arhgap15 Gene Detail
Summary
  • Symbol
    Arhgap15
  • Name
    Rho GTPase activating protein 15
  • Synonyms
    5830480G12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923367
    NCBI Gene: 76117
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:43638836-44285965 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 26.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13984 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923367
 protein coding gene Chr2:43638786-44285965 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025716
 protein coding gene Chr2:42746571-43417102 (+)
A/J MGP_AJ_G0025692
 protein coding gene Chr2:41025517-41669069 (+)
AKR/J MGP_AKRJ_G0025662
 protein coding gene Chr2:42293029-42949324 (+)
BALB/cJ MGP_BALBcJ_G0025687
 protein coding gene Chr2:41083593-41725187 (+)
C3H/HeJ MGP_C3HHeJ_G0025448
 protein coding gene Chr2:42234816-42894620 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026133
 protein coding gene Chr2:44036787-44718081 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023539
 protein coding gene Chr2:39358439-39986008 (+)
CAST/EiJ MGP_CASTEiJ_G0024913
 protein coding gene Chr2:42246199-42910891 (+)
CBA/J MGP_CBAJ_G0025428
 protein coding gene Chr2:45750099-46453451 (+)
DBA/2J MGP_DBA2J_G0025559
 protein coding gene Chr2:40693727-41333772 (+)
FVB/NJ MGP_FVBNJ_G0025521
 protein coding gene Chr2:40525866-41150114 (+)
LP/J MGP_LPJ_G0025647
 protein coding gene Chr2:42571871-43224146 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025552
 protein coding gene Chr2:46016933-46778547 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026191
 protein coding gene Chr2:42203325-42882949 (+)
PWK/PhJ MGP_PWKPhJ_G0024654
 protein coding gene Chr2:40625808-41264439 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024459
 protein coding gene Chr2:42297406-42949177 (+)
WSB/EiJ MGP_WSBEiJ_G0024980
 protein coding gene Chr2:42376329-43048107 (+)



Homology
more
  • Human Ortholog
    ARHGAP15, Rho GTPase activating protein 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP15, Rho GTPase activating protein 15
  • Synonyms
    BM046
  • Links
    NCBI Gene ID: 55843
    neXtProt AC: NX_Q53QZ3
    UniProt: Q53QZ3

  • Chr Location
    2q22.2-q22.3; chr2:143091362-143768352 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene display reduced leukocyte numbers and abnormally shaped macrophage. Chemotactic responses of macrophage are normal while neutrophile chemoattraction and bacterial pagocytosis are increased.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    35
  • cDNA Data
    31
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049744 Ensembl Gene Model | MGI Sequence Detail 647130 C57BL/6J ±  kb
transcript ENSMUST00000055776 Ensembl | MGI Sequence Detail 2604 Not Applicable  
polypeptide ENSMUSP00000056461 Ensembl | MGI Sequence Detail 481 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 31
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory