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Mcur1 Gene Detail
Summary
  • Symbol
    Mcur1
  • Name
    mitochondrial calcium uniporter regulator 1
  • Synonyms
    6230416A05Rik, Ccdc90a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923387
    NCBI Gene: 76137
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:43691869-43713667 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 21.60 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    804 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923387
 protein coding gene Chr13:43691869-43714284 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020501
 protein coding gene Chr13:42139313-42159195 (-)
A/J MGP_AJ_G0020455
 protein coding gene Chr13:40706362-40726293 (-)
AKR/J MGP_AKRJ_G0020433
 protein coding gene Chr13:41826431-41847804 (-)
BALB/cJ MGP_BALBcJ_G0020451
 protein coding gene Chr13:40918082-40937947 (-)
C3H/HeJ MGP_C3HHeJ_G0020250
 protein coding gene Chr13:41687153-41707020 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020884
 protein coding gene Chr13:43436388-43460715 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018471
 protein coding gene Chr13:38806114-38827234 (-)
CAST/EiJ MGP_CASTEiJ_G0019765
 protein coding gene Chr13:41536275-41556309 (-)
CBA/J MGP_CBAJ_G0020211
 protein coding gene Chr13:45284314-45304183 (-)
DBA/2J MGP_DBA2J_G0020333
 protein coding gene Chr13:40270027-40290137 (-)
FVB/NJ MGP_FVBNJ_G0020312
 protein coding gene Chr13:39792885-39812786 (-)
LP/J MGP_LPJ_G0020408
 protein coding gene Chr13:42380315-42400179 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020341
 protein coding gene Chr13:45181154-45202449 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020927
 protein coding gene Chr13:41493176-41513051 (-)
PWK/PhJ MGP_PWKPhJ_G0019520
 protein coding gene Chr13:40383485-40403526 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019350
 protein coding gene Chr13:40121227-40141228 (-)
WSB/EiJ MGP_WSBEiJ_G0019827
 protein coding gene Chr13:41801630-41821641 (-)



Homology
more
  • Human Ortholog
    MCUR1, mitochondrial calcium uniporter regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCUR1, mitochondrial calcium uniporter regulator 1
  • Synonyms
    C6orf79, CCDC90A, FMP32
  • Links
    NCBI Gene ID: 63933
    neXtProt AC: NX_Q96AQ8
    UniProt: Q96AQ8

  • Chr Location
    6p23; chr6:13786557-13814568 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, reduced body size and impaired mitochondrial calcium uptake.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    9
  • cDNA Data
    14
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021371 Ensembl Gene Model | MGI Sequence Detail 21799 C57BL/6J ±  kb
    transcript ENSMUST00000021800 Ensembl | MGI Sequence Detail 4339 Not Applicable  
    polypeptide ENSMUSP00000021800 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032262 coiled-coil domain-containing protein 90A, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR024461 Coiled-coil domain-containing protein 90-like
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2145454, MGI:3034305, MGI:3034505, MGI:3035052
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory