Ppp1r14c MGI Mouse Gene Detail - MGI:1923392 - protein phosphatase 1, regulatory inhibitor subunit 14C

Symbol

Ppp1r14c
Name

protein phosphatase 1, regulatory inhibitor subunit 14C
Synonyms

6330514J04Rik, KEPI

Feature Type

protein coding gene
IDs

MGI:1923392
NCBI Gene: 76142
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:3316057-3414975 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 2.06 cM
Mapping Data

1 experiment

SNPs within 2kb

2280 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923392	protein coding gene	Chr10:3315974-3414975 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016972	protein coding gene	Chr10:279742-388069 (+)
A/J	MGP_AJ_G0016950	protein coding gene	Chr10:270951-370411 (+)
AKR/J	MGP_AKRJ_G0016915	protein coding gene	Chr10:236634-348678 (+)
BALB/cJ	MGP_BALBcJ_G0016908	protein coding gene	Chr10:241631-345056 (+)
C3H/HeJ	MGP_C3HHeJ_G0016733	protein coding gene	Chr10:300201-402630 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017371	protein coding gene	Chr10:260581-369937 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015077	protein coding gene	Chr10:147468-240944 (+)
CAST/EiJ	MGP_CASTEiJ_G0016315	protein coding gene	Chr10:334854-440471 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0016813	protein coding gene	Chr10:290020-390788 (+)
FVB/NJ	MGP_FVBNJ_G0016808	protein coding gene	Chr10:237739-341638 (+)
LP/J	MGP_LPJ_G0016888	protein coding gene	Chr10:283960-398511 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016839	protein coding gene	Chr10:260893-368788 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017408	protein coding gene	Chr10:243125-347690 (+)
PWK/PhJ	MGP_PWKPhJ_G0016101	protein coding gene	Chr10:283117-383602 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015882	protein coding gene	Chr10:446317-596222 (+)
WSB/EiJ	MGP_WSBEiJ_G0016376	protein coding gene	Chr10:297122-403098 (+)

Human Ortholog

PPP1R14C, protein phosphatase 1 regulatory inhibitor subunit 14C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R14C, protein phosphatase 1 regulatory inhibitor subunit 14C
Synonyms

CPI17-like, KEPI, NY-BR-81
Links

HGNC:14952

NCBI Gene ID: 81706

neXtProt AC: NX_Q8TAE6

UniProt: Q8TAE6
Chr Location

6q25.1; chr6:150143044-150250392 (+) GRCh38

MGI Vertebrate Homology

Ppp1r14c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP1R14C
Gene Tree

Ppp1r14c

Diseases

1 with Ppp1r14c mouse models

Human Disease

Mouse Models

Coronavirus infectious disease

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

7 phenotypes from 1 allele in 2 genetic backgrounds
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for a knock-out allele exhibit some prenatal lethality and enhanced behavioral response to morphine.

less

All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

3
cDNA Data

31
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp1r14c

less

All Sequences

51
RefSeq

14
UniProt

3
CCDS

CCDS56669.1

Ensembl

ENSMUSG00000040653 (Evidence)
NCBI Gene

76142

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040653	Ensembl Gene Model \| MGI Sequence Detail	98919	C57BL/6J	± kb
transcript	ENSMUST00000043374	Ensembl \| MGI Sequence Detail	2617	Not Applicable
polypeptide	ENSMUSP00000045110	Ensembl \| MGI Sequence Detail	164	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000013114 protein phosphatase 1 regulatory subunit 14C

(term hierarchy)
InterPro Domains

IPR008025 CPI-17

IPR036658 CPI-17 superfamily
GlyGen

Q8R4S0 2 sites, 1 O-linked glycan (2 sites)

less

All nucleic 33

cDNA 31

Primer pair 2

Microarray probesets 6

Summaries

All 29

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:308818 Moreau MX, et al., Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Development. 2021 Jul 15;148(14):dev197962

TSS for Ppp1r14c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92203	Chr10:3316125-3316160 (+)	86 bp
Tssr92204	Chr10:3316170-3316207 (+)	132 bp
Tssr92205	Chr10:3316209-3316220 (+)	158 bp
Tssr3109	Chr10:3316271-3316283 (+)	220 bp
Tssr92206	Chr10:3316351-3316380 (+)	309 bp
Tssr92207	Chr10:3316506-3316590 (+)	491 bp
Tssr92208	Chr10:3341264-3341266 (+)	25,208 bp
Tssr92209	Chr10:3345782-3345814 (+)	29,741 bp
Tssr92210	Chr10:3402534-3402550 (+)	86,485 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24