Krt75 MGI Mouse Gene Detail - MGI:1923500

Symbol

Krt75
Name

keratin 75
Synonyms

4732468K03Rik, K6hf, Krt2-6hf, Krtcap1

Feature Type

protein coding gene
IDs

MGI:1923500
NCBI Gene: 109052
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:101471780-101482339 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.91 cM
Mapping Data

3 experiments

SNPs within 2kb

347 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923500	protein coding gene	Chr15:101471778-101482339 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022380	protein coding gene	Chr15:103663747-103674260 (-)
A/J	MGP_AJ_G0022342	protein coding gene	Chr15:99547004-99557566 (-)
AKR/J	MGP_AKRJ_G0022318	protein coding gene	Chr15:102586823-102597382 (-)
BALB/cJ	MGP_BALBcJ_G0022346	protein coding gene	Chr15:99656650-99667165 (-)
C3H/HeJ	MGP_C3HHeJ_G0022114	protein coding gene	Chr15:102680171-102690732 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022794	protein coding gene	Chr15:107532485-107543044 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020319	protein coding gene	Chr15:95401654-95412255 (-)
CAST/EiJ	MGP_CASTEiJ_G0021640	protein coding gene	Chr15:103531702-103542297 (-)
CBA/J	MGP_CBAJ_G0022084	protein coding gene	Chr15:111266204-111276759 (-)
DBA/2J	MGP_DBA2J_G0022212	protein coding gene	Chr15:98874014-98884573 (-)
FVB/NJ	MGP_FVBNJ_G0022191	protein coding gene	Chr15:97936134-97946693 (-)
LP/J	MGP_LPJ_G0022282	protein coding gene	Chr15:103819172-103829681 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022212	protein coding gene	Chr15:114913982-114924541 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022808	protein coding gene	Chr15:102628800-102639359 (-)
PWK/PhJ	MGP_PWKPhJ_G0021379	protein coding gene	Chr15:99047865-99058436 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021211	protein coding gene	Chr15:102513261-102523850 (-)
WSB/EiJ	MGP_WSBEiJ_G0021690	protein coding gene	Chr15:103272365-103282921 (-)

Human Ortholog

KRT75, keratin 75

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT75, keratin 75
Synonyms

CK-75, hK6hf, K6HF, K75, KB18, PFB
Links

HGNC:24431

NCBI Gene ID: 9119

neXtProt AC: NX_O95678

UniProt: O95678
Chr Location

12q13.13; chr12:52424070-52434371 (-) GRCh38

MGI Vertebrate Homology

Krt75 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: KRT75
Gene Tree

Krt75

less

References

1 with disease annotations

less

Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

2
Genomic Mutations

4 involving Krt75
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-in mutation that results in the deletion of the highly conserved asparagine residue (N159) in the helix initiation peptide of this gene develop hair shaft and nail abnormalities resembling pachyonychia congenita.

less

All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

8
cDNA Data

16
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KRT6A

less

All Sequences

37
RefSeq

2
UniProt

4
CCDS

CCDS27856.1

Ensembl

ENSMUSG00000022986 (Evidence)
NCBI Gene

109052

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022986	Ensembl Gene Model \| MGI Sequence Detail	10560	C57BL/6J	± kb
transcript	ENSMUST00000042957	Ensembl \| MGI Sequence Detail	3266	Not Applicable
polypeptide	ENSMUSP00000036246	Ensembl \| MGI Sequence Detail	551	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000009490 keratin, type II cytoskeletal 75

(term hierarchy)
InterPro Domains

IPR018039 Intermediate filament protein, conserved site

IPR039008 Intermediate filament, rod domain

IPR003054 Keratin, type II

IPR032444 Keratin type II head

less

All nucleic 21

Genomic 5

cDNA 16

Microarray probesets 2

less

MGI:2145919

Summaries

All 68

Developmental Gene Expression 10

Diseases 1

Gene Ontology 6

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Krt75:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136580	Chr15:101482318-101482348 (-)	6 bp
Tssr136579	Chr15:101482298-101482305 (-)	37 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24