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Cyrib Gene Detail
Summary
  • Symbol
    Cyrib
  • Name
    CYFIP related Rac1 interactor B
  • Synonyms
    0910001A06Rik, Fam49b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923520
    NCBI Gene: 223601
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:63800946-63932327 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 28.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2603 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923520
 protein coding gene Chr15:63800943-63932627 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021895
 protein coding gene Chr15:63386056-63418442 (-)
A/J MGP_AJ_G0021854
 protein coding gene Chr15:60929950-60972358 (-)
AKR/J MGP_AKRJ_G0021836
 protein coding gene Chr15:62627248-62757849 (-)
BALB/cJ MGP_BALBcJ_G0021861
 protein coding gene Chr15:61152145-61284815 (-)
C3H/HeJ MGP_C3HHeJ_G0021635
 protein coding gene Chr15:62769576-62915063 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022300
 protein coding gene Chr15:65824959-65893252 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019839
 protein coding gene Chr15:57843029-57975709 (-)
CAST/EiJ MGP_CASTEiJ_G0021153
 protein coding gene Chr15:63445133-63585948 (-)
CBA/J MGP_CBAJ_G0021601
 protein coding gene Chr15:68063290-68111909 (-)
DBA/2J MGP_DBA2J_G0021725
 protein coding gene Chr15:60763952-60896487 (-)
FVB/NJ MGP_FVBNJ_G0021707
 protein coding gene Chr15:59799298-59938699 (-)
LP/J MGP_LPJ_G0021797
 protein coding gene Chr15:63267391-63409954 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021730
 protein coding gene Chr15:73069950-73115472 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022322
 protein coding gene Chr15:63039671-63081864 (-)
PWK/PhJ MGP_PWKPhJ_G0020895
 protein coding gene Chr15:60865465-60905993 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020736
 protein coding gene Chr15:62859115-62900650 (-)
WSB/EiJ MGP_WSBEiJ_G0021205
 protein coding gene Chr15:63006899-63158399 (-)



Homology
more
  • Human Ortholog
    CYRIB, CYFIP related Rac1 interactor B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYRIB, CYFIP related Rac1 interactor B
  • Synonyms
    BM-009, CYRI, CYRI-B, FAM49B, L1
  • Links
    NCBI Gene ID: 51571
    neXtProt AC: NX_Q9NUQ9
    UniProt: Q9NUQ9

  • Chr Location
    8q24.21; chr8:129839593-130017504 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 3 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout causes increased embryonic death. Conditional knockout in myeloid cells results in increased susceptibility to Salmonella and M. tuberculosis infection-induced morbidity and mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    111
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022378 Ensembl Gene Model | MGI Sequence Detail 131382 C57BL/6J ±  kb
    transcript ENSMUST00000164532 Ensembl | MGI Sequence Detail 1770 Not Applicable  
    polypeptide ENSMUSP00000132486 Ensembl | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029475 CYFIP-related Rac1 interactor B
      (term hierarchy)
    • PDB
      7AJL
    • InterPro Domains
      IPR039789 CYFIP-related Rac1 interactor
      IPR009828 CYRIA/CYRIB, Rac1 binding domain
    • GlyGen
      Q921M7 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 111

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146195, MGI:6391260
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 10
      Phenotypes 40
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345628 Sisario D, et al., Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. Cells. 2024 Feb 6;13(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory