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Phf14 Gene Detail
Summary
  • Symbol
    Phf14
  • Name
    PHD finger protein 14
  • Synonyms
    1110001C23Rik, 4932409F11Rik, 5730446A07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923539
    NCBI Gene: 75725
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:11907808-12081204 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 5.01 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4483 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923539
 protein coding gene Chr6:11907728-12100155 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030455
 protein coding gene Chr6:8913802-9091406 (+)
A/J MGP_AJ_G0030428
 protein coding gene Chr6:8580258-8753069 (+)
AKR/J MGP_AKRJ_G0030355
 protein coding gene Chr6:8894986-9064664 (+)
BALB/cJ MGP_BALBcJ_G0030437
 protein coding gene Chr6:8600343-8773142 (+)
C3H/HeJ MGP_C3HHeJ_G0030151
 protein coding gene Chr6:8812318-8985003 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030892
 protein coding gene Chr6:9313858-9485201 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028103
 protein coding gene Chr6:7924479-8099592 (+)
CAST/EiJ MGP_CASTEiJ_G0029553
 protein coding gene Chr6:8676464-8852335 (+)
CBA/J MGP_CBAJ_G0030129
 protein coding gene Chr6:9439155-9633115 (+)
DBA/2J MGP_DBA2J_G0030273
 protein coding gene Chr6:8529869-8712225 (+)
FVB/NJ MGP_FVBNJ_G0030227
 protein coding gene Chr6:8444837-8618979 (+)
LP/J MGP_LPJ_G0030360
 protein coding gene Chr6:8877083-9066579 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030263
 protein coding gene Chr6:10008096-10253551 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030922
 protein coding gene Chr6:8757017-8936392 (+)
PWK/PhJ MGP_PWKPhJ_G0029267
 protein coding gene Chr6:8293645-8464782 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029103
 protein coding gene Chr6:8725943-8909074 (+)
WSB/EiJ MGP_WSBEiJ_G0029629
 protein coding gene Chr6:8723586-8892659 (+)



Homology
more
  • Human Ortholog
    PHF14, PHD finger protein 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHF14, PHD finger protein 14
  • Links
    NCBI Gene ID: 9678
    neXtProt AC: NX_O94880
    UniProt: O94880

  • Chr Location
    7p21.3; chr7:10973336-11169623 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete neonatal lethality due to respiratory failure, pulmonary wall hypertrophy, abnormal sternum ossification, and increased proliferation of bone marrow-derived mesenchymal cells and mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    964
  • Tissues
    97
  • cDNA Data
    91
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029629 Ensembl Gene Model | MGI Sequence Detail 173397 C57BL/6J ±  kb
    transcript ENSMUST00000115511 Ensembl | MGI Sequence Detail 3336 Not Applicable  
    polypeptide ENSMUSP00000111173 Ensembl | MGI Sequence Detail 941 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      cDNA 91
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922961, MGI:1922975, MGI:3034353, MGI:3035067
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory