Zdhhc5 MGI Mouse Gene Detail - MGI:1923573 - zinc finger, DHHC domain containing 5

Symbol

Zdhhc5
Name

zinc finger, DHHC domain containing 5
Synonyms

1110032A17Rik, Zisp

Feature Type

protein coding gene
IDs

MGI:1923573
NCBI Gene: 228136
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:84518314-84545524 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM
Mapping Data

2 experiments

SNPs within 2kb

500 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923573	protein coding gene	Chr2:84518264-84545524 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025906	protein coding gene	Chr2:85370113-85403101 (-)
A/J	MGP_AJ_G0025880	protein coding gene	Chr2:82073665-82100975 (-)
AKR/J	MGP_AKRJ_G0025850	protein coding gene	Chr2:84183213-84212786 (-)
BALB/cJ	MGP_BALBcJ_G0025877	protein coding gene	Chr2:82204976-82234180 (-)
C3H/HeJ	MGP_C3HHeJ_G0025636	protein coding gene	Chr2:84430377-84459857 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026323	protein coding gene	Chr2:88020033-88048884 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023725	protein coding gene	Chr2:78898091-78927135 (-)
CAST/EiJ	MGP_CASTEiJ_G0025097	protein coding gene	Chr2:84952619-84986340 (-)
CBA/J	MGP_CBAJ_G0025617	protein coding gene	Chr2:91167015-91196794 (-)
DBA/2J	MGP_DBA2J_G0025748	protein coding gene	Chr2:81611181-81639678 (-)
FVB/NJ	MGP_FVBNJ_G0025711	protein coding gene	Chr2:80862411-80892050 (-)
LP/J	MGP_LPJ_G0025836	protein coding gene	Chr2:85172661-85200794 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025741	protein coding gene	Chr2:93486573-93522861 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026379	protein coding gene	Chr2:84412442-84440378 (-)
PWK/PhJ	MGP_PWKPhJ_G0024841	protein coding gene	Chr2:81449289-81479983 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024645	protein coding gene	Chr2:84561388-84590866 (-)
WSB/EiJ	MGP_WSBEiJ_G0025167	protein coding gene	Chr2:85092181-85121859 (-)

Human Ortholog

ZDHHC5, zinc finger DHHC-type palmitoyltransferase 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZDHHC5, zinc finger DHHC-type palmitoyltransferase 5
Synonyms

DHHC5, ZNF375
Links

HGNC:18472

NCBI Gene ID: 25921

neXtProt AC: NX_Q9C0B5

UniProt: Q9C0B5
Chr Location

11q12.1; chr11:57667747-57701182 (+) GRCh38

MGI Vertebrate Homology

Zdhhc5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZDHHC5
Gene Tree

Zdhhc5

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Phenotype Summary

20 phenotypes from 4 alleles in 4 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

28
Targeted

6
Genomic Mutations

3 involving Zdhhc5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a hypomorphic allele exhibit partial prenatal lethality and impaired contextual conditioning. Mice homozygous for a conditional allele activated in adipocytes exhibit impaired fatty acid uptake and impairedadaptive thermogenesis.

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All GO Annotations

44
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

12
cDNA Data

14
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zdhhc5

ZFIN zdhhc5a, zdhhc5b

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All Sequences

44
RefSeq

2
UniProt

1
CCDS

CCDS16190.1

Ensembl

ENSMUSG00000034075 (Evidence)
NCBI Gene

228136

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034075	Ensembl Gene Model \| MGI Sequence Detail	27211	C57BL/6J	± kb
transcript	ENSMUST00000035840	Ensembl \| MGI Sequence Detail	4706	Not Applicable
polypeptide	ENSMUSP00000048198	Ensembl \| MGI Sequence Detail	715	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031752 palmitoyltransferase ZDHHC5

(term hierarchy)
EC

2.3.1.225
InterPro Domains

IPR051108 DHHC palmitoyltransferase

IPR001594 Palmitoyltransferase, DHHC domain
GlyGen

Q8VDZ4 1 site, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 6

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MGI:2138961

Summaries

All 64

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 25
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:352419 Balasubramanian A, et al., The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Sci Immunol. 2024 Apr 12;9(94):eadn1452

TSS for Zdhhc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25036	Chr2:84545654-84545668 (-)	-137 bp
Tssr25035	Chr2:84545638-84545649 (-)	-120 bp
Tssr25034	Chr2:84545621-84545631 (-)	-102 bp
Tssr25033	Chr2:84545607-84545619 (-)	-89 bp
Tssr25032	Chr2:84545504-84545562 (-)	-9 bp
Tssr25031	Chr2:84545472-84545495 (-)	40 bp
Tssr25030	Chr2:84545454-84545465 (-)	64 bp
Tssr25029	Chr2:84545368-84545447 (-)	116 bp
Tssr25028	Chr2:84542366-84542367 (-)	3,157 bp
Tssr25027	Chr2:84541212-84541227 (-)	4,304 bp
Tssr25026	Chr2:84522338-84522361 (-)	23,174 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24