Sephs1 MGI Mouse Gene Detail - MGI:1923580 - selenophosphate synthetase 1

Symbol

Sephs1
Name

selenophosphate synthetase 1
Synonyms

1110046B24Rik, SPS1

Feature Type

protein coding gene
IDs

MGI:1923580
NCBI Gene: 109079
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:4886375-4915368 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 3.02 cM
Mapping Data

2 experiments

SNPs within 2kb

729 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923580	protein coding gene	Chr2:4886375-4915368 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025316	protein coding gene	Chr2:1954443-1989973 (+)
A/J	MGP_AJ_G0025293	protein coding gene	Chr2:1860530-1890009 (+)
AKR/J	MGP_AKRJ_G0025261	protein coding gene	Chr2:1896241-1928365 (+)
BALB/cJ	MGP_BALBcJ_G0025289	protein coding gene	Chr2:1838317-1871804 (+)
C3H/HeJ	MGP_C3HHeJ_G0025049	protein coding gene	Chr2:1883813-1920301 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025731	protein coding gene	Chr2:1972879-2006434 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023145	protein coding gene	Chr2:1713939-1740056 (+)
CAST/EiJ	MGP_CASTEiJ_G0024512	protein coding gene	Chr2:1910963-1945518 (+)
CBA/J	MGP_CBAJ_G0025028	protein coding gene	Chr2:2052470-2090232 (+)
DBA/2J	MGP_DBA2J_G0025160	protein coding gene	Chr2:1829488-1858918 (+)
FVB/NJ	MGP_FVBNJ_G0025122	protein coding gene	Chr2:1817503-1848218 (+)
LP/J	MGP_LPJ_G0025246	protein coding gene	Chr2:1935148-1967880 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025154	protein coding gene	Chr2:1958161-1992699 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025789	protein coding gene	Chr2:1898365-1933008 (+)
PWK/PhJ	MGP_PWKPhJ_G0024262	protein coding gene	Chr2:1810736-1840387 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024063	protein coding gene	Chr2:1906381-1934922 (+)
WSB/EiJ	MGP_WSBEiJ_G0024582	protein coding gene	Chr2:1919543-1951979 (+)

Human Ortholog

SEPHS1, selenophosphate synthetase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEPHS1, selenophosphate synthetase 1
Synonyms

SELD, SPS, SPS1
Links

HGNC:19685

NCBI Gene ID: 22929

neXtProt AC: NX_P49903

UniProt: P49903
Chr Location

10p13; chr10:13317428-13348298 (-) GRCh38

MGI Vertebrate Homology

Sephs1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SEPHS1
Protein SuperFamily

Selenphspht_syn
Gene Tree

Sephs1

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Gene trapped

32
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic growth retardation and complete lethality by E14.5 with failure of the amnion to separate from the yolk sac. Mice homozygous for a conditional allele activated in the liver exhibit reduced liver iron and manganese levels.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

100
cDNA Data

138
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sephs1

ZFIN sephs1

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All Sequences

59
RefSeq

12
UniProt

4
CCDS

CCDS15659.1

Ensembl

ENSMUSG00000026662 (Evidence)
NCBI Gene

109079

			Length	Strain/Species	Flank
genomic	109079	NCBI Gene Model \| MGI Sequence Detail	28994	C57BL/6J	± kb
transcript	NM_001362707	RefSeq \| MGI Sequence Detail	5381	Not Specified
polypeptide	Q8BH69	UniProt \| EBI \| MGI Sequence Detail	392	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014643 selenide, water dikinase 1

(term hierarchy)
EC

2.7.9.3
InterPro Domains

IPR010918 PurM-like, C-terminal domain

IPR036676 PurM-like, C-terminal domain superfamily

IPR016188 PurM-like, N-terminal domain

IPR036921 PurM-like, N-terminal domain superfamily

IPR004536 Selenophosphate synthetase

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All nucleic 139

cDNA 139

Microarray probesets 7

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MGI:2138799, MGI:2138992, MGI:2139306

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:336812 Bang J, et al., SEPHS1: Its evolution, function and roles in development and diseases. Arch Biochem Biophys. 2022 Nov 15;730:109426

TSS for Sephs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15977	Chr2:4886298-4886382 (+)	-35 bp
Tssr15978	Chr2:4886567-4886583 (+)	200 bp
Tssr15979	Chr2:4886609-4886647 (+)	253 bp
Tssr15980	Chr2:4886660-4886671 (+)	291 bp
Tssr15981	Chr2:4887015-4887063 (+)	664 bp
Tssr15982	Chr2:4887082-4887104 (+)	718 bp
Tssr15983	Chr2:4900685-4900691 (+)	14,313 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24