Trmt5 MGI Mouse Gene Detail - MGI:1923607 - TRM5 tRNA methyltransferase 5

Symbol

Trmt5
Name

TRM5 tRNA methyltransferase 5
Synonyms

2610027O18Rik

Feature Type

protein coding gene
IDs

MGI:1923607
NCBI Gene: 76357
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:73326785-73333484 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 30.42 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

286 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923607	protein coding gene	Chr12:73315289-73333754 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019835	protein coding gene	Chr12:73175877-73182175 (-)
A/J	MGP_AJ_G0019793	protein coding gene	Chr12:70439009-70445714 (-)
AKR/J	MGP_AKRJ_G0019768	protein coding gene	Chr12:72574295-72580596 (-)
BALB/cJ	MGP_BALBcJ_G0019773	protein coding gene	Chr12:70919513-70925804 (-)
C3H/HeJ	MGP_C3HHeJ_G0019578	protein coding gene	Chr12:73004624-73010927 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020225	protein coding gene	Chr12:75453834-75460135 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017843	protein coding gene	Chr12:67882760-67888589 (-)
CAST/EiJ	MGP_CASTEiJ_G0019130	protein coding gene	Chr12:67801996-67808277 (-)
CBA/J	MGP_CBAJ_G0019548	protein coding gene	Chr12:78329759-78336170 (-)
DBA/2J	MGP_DBA2J_G0019664	protein coding gene	Chr12:70334260-70340549 (-)
FVB/NJ	MGP_FVBNJ_G0019651	protein coding gene	Chr12:69182389-69188670 (-)
LP/J	MGP_LPJ_G0019736	protein coding gene	Chr12:73200200-73206460 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019690	protein coding gene	Chr12:81463778-81470477 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020260	protein coding gene	Chr12:72059615-72065918 (-)
PWK/PhJ	MGP_PWKPhJ_G0018895	protein coding gene	Chr12:64652147-64658939 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018690	protein coding gene	Chr12:66482559-66488947 (-)
WSB/EiJ	MGP_WSBEiJ_G0019181	protein coding gene	Chr12:72649753-72656866 (-)

Human Ortholog

TRMT5, tRNA methyltransferase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRMT5, tRNA methyltransferase 5
Synonyms

COXPD26, KIAA1393, PNSED, TRM5
Links

HGNC:23141

NCBI Gene ID: 57570

neXtProt AC: NX_Q32P41

UniProt: Q32P41
Chr Location

14q23.1; chr14:60971441-60981690 (-) GRCh38

MGI Vertebrate Homology

Trmt5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRMT5
Gene Tree

Trmt5

Diseases

1 with human TRMT5 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 26 IDs combined oxidative phosphorylation deficiency 26 DOID:0111490 OMIM:616539 ORDO:477684

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
1 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

5
Targeted

3
Genomic Mutations

1 involving Trmt5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

33

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trmt5

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All Sequences

58
RefSeq

21
UniProt

3
CCDS

CCDS36474.1

Ensembl

ENSMUSG00000034442 (Evidence)
NCBI Gene

76357

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034442	Ensembl Gene Model \| MGI Sequence Detail	6700	C57BL/6J	± kb
transcript	ENSMUST00000116420	Ensembl \| MGI Sequence Detail	2066	Not Applicable
polypeptide	ENSMUSP00000112121	Ensembl \| MGI Sequence Detail	501	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016682 tRNA (guanine-N(1)-)-methyltransferase

(term hierarchy)
EC

2.1.1.228
InterPro Domains

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

IPR030382 SAM-dependent methyltransferase TRM5/TYW2-type

IPR025792 tRNA (guanine(37)-N(1))-methyltransferase, eukaryotic

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All nucleic 33

cDNA 33

Microarray probesets 3

Summaries

All 35

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trmt5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116649	Chr12:73333964-73333978 (-)	-487 bp
Tssr116648	Chr12:73333472-73333526 (-)	-15 bp
Tssr116647	Chr12:73331772-73331802 (-)	1,697 bp
Tssr116646	Chr12:73331748-73331766 (-)	1,727 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24