Ropn1 MGI Mouse Gene Detail - MGI:1923628 - ropporin, rhophilin associated protein 1

Symbol

Ropn1
Name

ropporin, rhophilin associated protein 1
Synonyms

1700008N21Rik, ODF6, RHPNAP1, ropporin

Feature Type

protein coding gene
IDs

MGI:1923628
NCBI Gene: 76378
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:34470291-34498988 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 24.44 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

832 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923628	protein coding gene	Chr16:34470271-34498988 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022762	protein coding gene	Chr16:32930487-32960681 (+)
A/J	MGP_AJ_G0022727	protein coding gene	Chr16:31324083-31354618 (+)
AKR/J	MGP_AKRJ_G0022700	protein coding gene	Chr16:32426660-32460503 (+)
BALB/cJ	MGP_BALBcJ_G0022729	protein coding gene	Chr16:31447843-31478467 (+)
C3H/HeJ	MGP_C3HHeJ_G0022494	protein coding gene	Chr16:32566296-32595456 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023178	protein coding gene	Chr16:33637117-33666139 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020696	protein coding gene	Chr16:31673796-31702412 (+)
CAST/EiJ	MGP_CASTEiJ_G0022022	protein coding gene	Chr16:32762976-32794413 (+)
CBA/J	MGP_CBAJ_G0022464	protein coding gene	Chr16:35008265-35041737 (+)
DBA/2J	MGP_DBA2J_G0022597	protein coding gene	Chr16:31156832-31185745 (+)
FVB/NJ	MGP_FVBNJ_G0022572	protein coding gene	Chr16:31148210-31178036 (+)
LP/J	MGP_LPJ_G0022664	protein coding gene	Chr16:32629179-32662620 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022591	protein coding gene	Chr16:34323566-34368591 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023190	protein coding gene	Chr16:32461278-32492423 (+)
PWK/PhJ	MGP_PWKPhJ_G0021763	protein coding gene	Chr16:31540421-31572739 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021594	protein coding gene	Chr16:32283491-32312052 (+)
WSB/EiJ	MGP_WSBEiJ_G0022066	protein coding gene	Chr16:32410243-32441274 (+)

Human Ortholog

ROPN1, rhophilin associated tail protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ROPN1, rhophilin associated tail protein 1
Synonyms

CT91, ODF6, RHPNAP1, ROPN1A, ropporin
Links

HGNC:17692

NCBI Gene ID: 54763

neXtProt AC: NX_Q9HAT0

UniProt: Q9HAT0
Chr Location

3q21.1; chr3:123968521-123992178 (-) GRCh38

Human Ortholog

ROPN1B, rhophilin associated tail protein 1B
Links

HGNC:31927

NCBI Gene ID: 152015

neXtProt AC: NX_Q9BZX4

UniProt: Q9BZX4
Chr Location

3q21.2; chr3:125969160-125983454 (+) GRCh38

MGI Vertebrate Homology

Ropn1 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ROPN1, ROPN1B
Gene Tree

Ropn1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Gene trapped

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit reduced sperm motility and reduced male fertility.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS28137.1

Ensembl

ENSMUSG00000022832 (Evidence)
NCBI Gene

76378

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022832	Ensembl Gene Model \| MGI Sequence Detail	28698	C57BL/6J	± kb
transcript	ENSMUST00000023530	Ensembl \| MGI Sequence Detail	875	Not Applicable
polypeptide	ENSMUSP00000023530	Ensembl \| MGI Sequence Detail	212	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000034329 ropporin-1

(term hierarchy)
InterPro Domains

IPR047844 Ropporin, dimerization/docking domain

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All nucleic 13

cDNA 13

Microarray probesets 3

Summaries

All 30

Gene Ontology 8

Phenotypes 4
Earliest

J:69446 Fujita A, et al., Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. J Cell Sci. 2000 Jan;113(Pt 1):103-12
Latest

J:319365 Liu S, et al., CFAP61 is required for sperm flagellum formation and male fertility in human and mouse. Development. 2021 Dec 1;148(23):dev199805

TSS for Ropn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138148	Chr16:34470263-34470287 (+)	-16 bp
Tssr138149	Chr16:34470290-34470314 (+)	11 bp
Tssr138150	Chr16:34470318-34470327 (+)	32 bp
Tssr138151	Chr16:34471572-34471589 (+)	1,290 bp
Tssr138152	Chr16:34471596-34471605 (+)	1,310 bp
Tssr138153	Chr16:34481122-34481128 (+)	10,834 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24