Fam209 MGI Mouse Gene Detail - MGI:1923676 - family with sequence similarity 209

Symbol

Fam209
Name

family with sequence similarity 209
Synonyms

1700029J11Rik

Feature Type

protein coding gene
IDs

MGI:1923676
NCBI Gene: 76426
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:172314474-172316236 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 94.87 cM, cytoband H3
Mapping Data

2 experiments

SNPs within 2kb

198 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923676	protein coding gene	Chr2:172314440-172316251 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026947	protein coding gene	Chr2:178645066-178646877 (+)
A/J	MGP_AJ_G0026914	protein coding gene	Chr2:171168307-171170118 (+)
AKR/J	MGP_AKRJ_G0026885	protein coding gene	Chr2:176337608-176339419 (+)
BALB/cJ	MGP_BALBcJ_G0026923	protein coding gene	Chr2:171565682-171567493 (+)
C3H/HeJ	MGP_C3HHeJ_G0026665	protein coding gene	Chr2:176688156-176689967 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027370	protein coding gene	Chr2:183814789-183816600 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024740	protein coding gene	Chr2:164417005-164418797 (+)
CAST/EiJ	MGP_CASTEiJ_G0026123	protein coding gene	Chr2:177360152-177361920 (+)
CBA/J	MGP_CBAJ_G0026642	protein coding gene	Chr2:190671030-190672841 (+)
DBA/2J	MGP_DBA2J_G0026780	protein coding gene	Chr2:170262262-170264073 (+)
FVB/NJ	MGP_FVBNJ_G0026746	protein coding gene	Chr2:168865478-168867289 (+)
LP/J	MGP_LPJ_G0026881	protein coding gene	Chr2:178579991-178581802 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026765	protein coding gene	Chr2:193664683-193666494 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027427	protein coding gene	Chr2:176306330-176308141 (+)
PWK/PhJ	MGP_PWKPhJ_G0025860	protein coding gene	Chr2:170029709-170031477 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025660	protein coding gene	Chr2:175303330-175305116 (+)
WSB/EiJ	MGP_WSBEiJ_G0026196	protein coding gene	Chr2:177279270-177281081 (+)

Human Ortholog

FAM209A, family with sequence similarity 209 member A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM209A, family with sequence similarity 209 member A
Synonyms

C20orf106, dJ1153D9.3
Links

HGNC:16100

NCBI Gene ID: 200232

neXtProt AC: NX_Q5JX71

UniProt: Q5JX71
Chr Location

20q13.31; chr20:56517187-56533590 (+) GRCh38

Human Ortholog

FAM209B, family with sequence similarity 209 member B
Synonyms

C20orf107, dJ1153D9.4
Links

HGNC:16101

NCBI Gene ID: 388799

neXtProt AC: NX_Q5JX69

UniProt: Q5JX69
Chr Location

20q13.31; chr20:56533246-56536520 (+) GRCh38

MGI Vertebrate Homology

Fam209 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FAM209A, FAM209B
Gene Tree

Fam209

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Phenotype Summary

8 phenotypes from 3 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

4
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility with asthenozoospermia and globozoospermia.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS50809.1

Ensembl

ENSMUSG00000027505 (Evidence)
NCBI Gene

76426

			Length	Strain/Species	Flank
genomic	76426	NCBI Gene Model \| MGI Sequence Detail	1763	C57BL/6J	± kb
transcript	NM_029608	RefSeq \| MGI Sequence Detail	649	Not Specified
polypeptide	A2APA5	UniProt \| EBI \| MGI Sequence Detail	170	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR027943 FAM209 family

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All nucleic 13

cDNA 13

Microarray probesets 4

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:347872 Jin HJ, et al., Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice. Elife. 2024 Apr 4;13

TSS for Fam209:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21958	Chr2:172314432-172314455 (+)	-30 bp
Tssr21959	Chr2:172314458-172314473 (+)	-8 bp
Tssr21960	Chr2:172314475-172314487 (+)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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