Supt3 MGI Mouse Gene Detail - MGI:1923723 - SPT3, SAGA and STAGA complex component

Symbol

Supt3
Name

SPT3, SAGA and STAGA complex component
Synonyms

2310066G22Rik, SPT3, SPT3L, Supt3h

Feature Type

protein coding gene
IDs

MGI:1923723
NCBI Gene: 109115
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:45088039-45430177 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 21.56 cM
Mapping Data

2 experiments

SNPs within 2kb

6550 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923723	protein coding gene	Chr17:45088005-45430181 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023785	protein coding gene	Chr17:45754666-46101541 (+)
A/J	MGP_AJ_G0023743	protein coding gene	Chr17:44685840-45014842 (+)
AKR/J	MGP_AKRJ_G0023714	protein coding gene	Chr17:44968381-45310070 (+)
BALB/cJ	MGP_BALBcJ_G0023747	protein coding gene	Chr17:44562897-44906903 (+)
C3H/HeJ	MGP_C3HHeJ_G0023511	protein coding gene	Chr17:45679497-46029828 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024190	protein coding gene	Chr17:47755818-48107324 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021640	protein coding gene	Chr17:41488930-41822148 (+)
CAST/EiJ	MGP_CASTEiJ_G0022992	protein coding gene	Chr17:45756979-46113800 (+)
CBA/J	MGP_CBAJ_G0023487	protein coding gene	Chr17:49445294-49807907 (+)
DBA/2J	MGP_DBA2J_G0023613	protein coding gene	Chr17:43481033-43811046 (+)
FVB/NJ	MGP_FVBNJ_G0023580	protein coding gene	Chr17:43050043-43385244 (+)
LP/J	MGP_LPJ_G0023694	protein coding gene	Chr17:46420853-46765509 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023609	protein coding gene	Chr17:49034767-49396706 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024235	protein coding gene	Chr17:45331619-45667575 (+)
PWK/PhJ	MGP_PWKPhJ_G0022737	protein coding gene	Chr17:42764086-43102339 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022552	protein coding gene	Chr17:42189507-42538837 (+)
WSB/EiJ	MGP_WSBEiJ_G0023057	protein coding gene	Chr17:45851133-46198622 (+)

Human Ortholog

SUPT3H, SPT3 homolog, SAGA and STAGA complex component

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SUPT3H, SPT3 homolog, SAGA and STAGA complex component
Synonyms

SPT3, SPT3L
Links

HGNC:11466

NCBI Gene ID: 8464

neXtProt AC: NX_O75486

UniProt: O75486
Chr Location

6p21.1; chr6:44809057-45377953 (-) GRCh38

MGI Vertebrate Homology

Supt3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SUPT3H
Gene Tree

Supt3

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Gene trapped

12
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit defects in chorion formation and placentation, abnormal trophoblast layer morphology, and complete lethality throughout fetal growth and development.

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

15
cDNA Data

31
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase supt3h

ZFIN supt3h

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All Sequences

60
RefSeq

15
UniProt

5
CCDS

CCDS37625.1

Ensembl

ENSMUSG00000038954 (Evidence)
NCBI Gene

109115

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038954	Ensembl Gene Model \| MGI Sequence Detail	342139	C57BL/6J	± kb
transcript	ENSMUST00000129416	Ensembl \| MGI Sequence Detail	1218	Not Applicable
polypeptide	ENSMUSP00000120197	Ensembl \| MGI Sequence Detail	406	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR009072 Histone-fold

IPR003195 Transcription initiation factor IID, subunit 13

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All nucleic 31

cDNA 31

Microarray probesets 3

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MGI:2146819

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 8
Earliest

J:320277 Ogryzko VV, et al., Histone-like TAFs within the PCAF histone acetylase complex. Cell. 1998 Jul 10;94(1):35-44
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Supt3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144761	Chr17:45088014-45088085 (+)	11 bp
Tssr144762	Chr17:45088087-45088163 (+)	86 bp
Tssr144763	Chr17:45088181-45088220 (+)	162 bp
Tssr144764	Chr17:45150204-45150208 (+)	62,167 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24