Tmem182 MGI Mouse Gene Detail - MGI:1923725

Symbol

Tmem182
Name

transmembrane protein 182
Synonyms

2310079P10Rik

Feature Type

protein coding gene
IDs

MGI:1923725
NCBI Gene: 381339
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:40844761-40896047 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 20.01 cM
Mapping Data

2 experiments

SNPs within 2kb

1907 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923725	protein coding gene	Chr1:40844738-40896047 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015973	protein coding gene	Chr1:39622030-39675006 (+)
A/J	MGP_AJ_G0015957	protein coding gene	Chr1:38498944-38551269 (+)
AKR/J	MGP_AKRJ_G0015912	protein coding gene	Chr1:38970224-39024153 (+)
BALB/cJ	MGP_BALBcJ_G0015911	protein coding gene	Chr1:38148984-38199071 (+)
C3H/HeJ	MGP_C3HHeJ_G0015744	protein coding gene	Chr1:39291305-39346579 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016364	protein coding gene	Chr1:41283903-41335649 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014086	protein coding gene	Chr1:35406710-35456509 (+)
CAST/EiJ	MGP_CASTEiJ_G0015325	protein coding gene	Chr1:39181402-39234568 (+)
CBA/J	MGP_CBAJ_G0015716	protein coding gene	Chr1:42486364-42542284 (+)
DBA/2J	MGP_DBA2J_G0015817	protein coding gene	Chr1:37777126-37828557 (+)
FVB/NJ	MGP_FVBNJ_G0015819	protein coding gene	Chr1:37314991-37364970 (+)
LP/J	MGP_LPJ_G0015887	protein coding gene	Chr1:39971004-40022904 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015839	protein coding gene	Chr1:44460589-44526140 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016411	protein coding gene	Chr1:39137890-39190578 (+)
PWK/PhJ	MGP_PWKPhJ_G0015108	protein coding gene	Chr1:37594727-37646297 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014890	protein coding gene	Chr1:39110833-39161553 (+)
WSB/EiJ	MGP_WSBEiJ_G0015387	protein coding gene	Chr1:39112162-39162466 (+)

Human Ortholog

TMEM182, transmembrane protein 182

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM182, transmembrane protein 182
Links

HGNC:26391

NCBI Gene ID: 130827

neXtProt AC: NX_Q6ZP80

UniProt: Q6ZP80
Chr Location

2q12.1; chr2:102736905-103019900 (+) GRCh38

MGI Vertebrate Homology

Tmem182 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMEM182
Gene Tree

Tmem182

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

1 involving Tmem182
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show increased body weight, muscle mass, muscle fiber number, and muscle fiber diameter and accelerated skeletal muscle regeneration.

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All GO Annotations

6
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem182

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All Sequences

37
RefSeq

6
UniProt

1
CCDS

CCDS35550.1

Ensembl

ENSMUSG00000079588 (Evidence)
NCBI Gene

381339

			Length	Strain/Species	Flank
genomic	ENSMUSG00000079588	Ensembl Gene Model \| MGI Sequence Detail	51287	C57BL/6J	± kb
transcript	ENSMUST00000114765	Ensembl \| MGI Sequence Detail	2716	Not Applicable
polypeptide	ENSMUSP00000110413	Ensembl \| MGI Sequence Detail	229	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032253 transmembrane protein 182

(term hierarchy)
InterPro Domains

IPR004031 PMP-22/EMP/MP20/Claudin

IPR026763 Transmembrane protein 182
GlyGen

B2RVY9 4 sites

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All nucleic 3

cDNA 3

Microarray probesets 3

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MGI:2138224

Summaries

All 29

Gene Ontology 3

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tmem182:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6503	Chr1:40844738-40844852 (+)	34 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24