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Eif4a3 Gene Detail
Summary
  • Symbol
    Eif4a3
  • Name
    eukaryotic translation initiation factor 4A3
  • Synonyms
    2400003O03Rik, Ddx48, mKIAA0111
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923731
    NCBI Gene: 192170
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119179189-119190869 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    411 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923731
 protein coding gene Chr11:119179189-119190915 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019478
 protein coding gene Chr11:123660966-123679822 (-)
A/J MGP_AJ_G0019446
 protein coding gene Chr11:118190242-118202411 (-)
AKR/J MGP_AKRJ_G0019416
 protein coding gene Chr11:121748615-121760653 (-)
BALB/cJ MGP_BALBcJ_G0019421
 protein coding gene Chr11:118548413-118560324 (-)
C3H/HeJ MGP_C3HHeJ_G0019227
 protein coding gene Chr11:122064776-122076418 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019870
 protein coding gene Chr11:127435658-127452279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017495
 protein coding gene Chr11:115184330-115195408 (-)
CAST/EiJ MGP_CASTEiJ_G0018781
 protein coding gene Chr11:123519713-123534745 (-)
CBA/J MGP_CBAJ_G0019198
 protein coding gene Chr11:132387788-132407440 (-)
DBA/2J MGP_DBA2J_G0019310
 protein coding gene Chr11:117562413-117574783 (-)
FVB/NJ MGP_FVBNJ_G0019302
 protein coding gene Chr11:117229446-117241472 (-)
LP/J MGP_LPJ_G0019380
 protein coding gene Chr11:123975295-123990335 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019335
 protein coding gene Chr11:131322981-131337806 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019909
 protein coding gene Chr11:122420817-122434436 (-)
PWK/PhJ MGP_PWKPhJ_G0018547
 protein coding gene Chr11:118968566-118980471 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018339
 protein coding gene Chr11:122176476-122189877 (-)
WSB/EiJ MGP_WSBEiJ_G0018833
 protein coding gene Chr11:122391058-122408790 (-)



Homology
more
  • Human Ortholog
    EIF4A3, eukaryotic translation initiation factor 4A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4A3, eukaryotic translation initiation factor 4A3
  • Synonyms
    DDX48, eIF-4A-III, eIF4A-III, eIF4AIII, Fal1, MUK34, NMP265, NUK34, RCPS
  • Links
    NCBI Gene ID: 9775
    neXtProt AC: NX_P38919
    UniProt: P38919

  • Chr Location
    17q25.3; chr17:80134369-80147151 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EIF4A3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    8
  • cDNA Data
    14
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 192170 NCBI Gene Model | MGI Sequence Detail 11681 C57BL/6J ±  kb
    transcript NM_138669 RefSeq | MGI Sequence Detail 1489 FVB/N  
    polypeptide Q91VC3 UniProt | EBI | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006988 eukaryotic initiation factor 4A-III
      (term hierarchy)
    • GlyGen
      Q91VC3 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 1
      Other 1

      Microarray probesets 8
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341383 Salamon I, et al., Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Nat Commun. 2023 Sep 27;14(1):6025
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory