Ppp1r3g MGI Mouse Gene Detail - MGI:1923737 - protein phosphatase 1, regulatory subunit 3G

Symbol

Ppp1r3g
Name

protein phosphatase 1, regulatory subunit 3G
Synonyms

1600032L17Rik

Feature Type

protein coding gene
IDs

MGI:1923737
NCBI Gene: 76487
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:36142822-36154371 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 14.44 cM
Mapping Data

1 experiment

SNPs within 2kb

422 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923737	protein coding gene	Chr13:36142816-36154371 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020460	protein coding gene	Chr13:34160180-34173246 (+)
A/J	MGP_AJ_G0020414	protein coding gene	Chr13:33129371-33142511 (+)
AKR/J	MGP_AKRJ_G0020392	protein coding gene	Chr13:33956076-33967608 (+)
BALB/cJ	MGP_BALBcJ_G0020410	protein coding gene	Chr13:33194167-33208817 (+)
C3H/HeJ	MGP_C3HHeJ_G0020209	protein coding gene	Chr13:33814493-33837225 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020843	protein coding gene	Chr13:35307065-35322018 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018430	protein coding gene	Chr13:31349239-31361119 (+)
CAST/EiJ	MGP_CASTEiJ_G0019724	protein coding gene	Chr13:33535475-33548463 (+)
CBA/J	MGP_CBAJ_G0020170	protein coding gene	Chr13:36819955-36838963 (+)
DBA/2J	MGP_DBA2J_G0020292	protein coding gene	Chr13:32652531-32664535 (+)
FVB/NJ	MGP_FVBNJ_G0020271	protein coding gene	Chr13:32194645-32207720 (+)
LP/J	MGP_LPJ_G0020367	protein coding gene	Chr13:34390858-34402979 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020301	protein coding gene	Chr13:36975390-36989263 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020886	protein coding gene	Chr13:33548766-33561100 (+)
PWK/PhJ	MGP_PWKPhJ_G0019479	protein coding gene	Chr13:32764815-32777019 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019310	protein coding gene	Chr13:32257084-32268890 (+)
WSB/EiJ	MGP_WSBEiJ_G0019786	protein coding gene	Chr13:33907566-33922284 (+)

Human Ortholog

PPP1R3G, protein phosphatase 1 regulatory subunit 3G

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R3G, protein phosphatase 1 regulatory subunit 3G
Links

HGNC:14945

NCBI Gene ID: 648791

neXtProt AC: NX_B7ZBB8

UniProt: B7ZBB8
Chr Location

6

MGI Vertebrate Homology

Ppp1r3g stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP1R3G
Gene Tree

Ppp1r3g

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

1
Genomic Mutations

1 involving Ppp1r3g
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Under a high-fat diet, mice homozygous for a knock-out allele show decreased susceptibility to diet-induced obesity and hepatic steatosis along with a higher metabolic rate, increased food intake, and decreased glycogen levels in liver and adipose tissue.

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All GO Annotations

18
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

6
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

6
UniProt

1
CCDS

CCDS49237.1

Ensembl

ENSMUSG00000050423 (Evidence)
NCBI Gene

76487

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050423	Ensembl Gene Model \| MGI Sequence Detail	11550	C57BL/6J	± kb
transcript	ENSMUST00000225537	Ensembl \| MGI Sequence Detail	2389	Not Applicable
polypeptide	ENSMUSP00000153702	Ensembl \| MGI Sequence Detail	347	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030207 protein phosphatase 1 regulatory subunit 3G

(term hierarchy)
InterPro Domains

IPR005036 CBM21 (carbohydrate binding type-21) domain

IPR038175 CBM21 domain superfamily

IPR050782 Protein phosphatase 1 regulatory subunit 3

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All nucleic 9

Genomic 2

cDNA 6

Primer pair 1

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 5
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:331156 Du J, et al., RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1gamma promote apoptosis and necroptosis. Nat Commun. 2021 Dec 3;12(1):7067

TSS for Ppp1r3g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119250	Chr13:36142833-36142845 (+)	17 bp
Tssr119251	Chr13:36142855-36142869 (+)	40 bp
Tssr4042	Chr13:36145371-36145376 (+)	2,552 bp
Tssr119252	Chr13:36147110-36147114 (+)	4,290 bp
Tssr119253	Chr13:36147553-36147558 (+)	4,734 bp
Tssr119254	Chr13:36151843-36151871 (+)	9,035 bp
Tssr119255	Chr13:36152450-36152454 (+)	9,630 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24