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Tmub1 Gene Detail
Summary
  • Symbol
    Tmub1
  • Name
    transmembrane and ubiquitin-like domain containing 1
  • Synonyms
    2010004O20Rik, Hops
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923764
    NCBI Gene: 64295
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24650456-24652852 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 11.79 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923764
 protein coding gene Chr5:24650456-24652859 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029345
 protein coding gene Chr5:22173124-22175520 (-)
A/J MGP_AJ_G0029311
 protein coding gene Chr5:21418270-21420666 (-)
AKR/J MGP_AKRJ_G0029262
 protein coding gene Chr5:22279726-22282122 (-)
BALB/cJ MGP_BALBcJ_G0029322
 protein coding gene Chr5:21931364-21933760 (-)
C3H/HeJ MGP_C3HHeJ_G0029042
 protein coding gene Chr5:22393972-22396368 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029775
 protein coding gene Chr5:23666466-23668862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027013
 protein coding gene Chr5:19360510-19362920 (-)
CAST/EiJ MGP_CASTEiJ_G0028454
 protein coding gene Chr5:21566983-21569381 (-)
CBA/J MGP_CBAJ_G0029009
 protein coding gene Chr5:24054369-24056765 (-)
DBA/2J MGP_DBA2J_G0029160
 protein coding gene Chr5:21711338-21713736 (-)
FVB/NJ MGP_FVBNJ_G0029118
 protein coding gene Chr5:21080592-21082988 (-)
LP/J MGP_LPJ_G0029244
 protein coding gene Chr5:22577890-22580286 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029147
 protein coding gene Chr5:25176999-25179395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029809
 protein coding gene Chr5:21922286-21924684 (-)
PWK/PhJ MGP_PWKPhJ_G0028178
 protein coding gene Chr5:20789565-20791963 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028009
 protein coding gene Chr5:21277554-21279931 (-)
WSB/EiJ MGP_WSBEiJ_G0028534
 protein coding gene Chr5:21990554-21992952 (-)



Homology
more
  • Human Ortholog
    TMUB1, transmembrane and ubiquitin like domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMUB1, transmembrane and ubiquitin like domain containing 1
  • Synonyms
    C7orf21, DULP, HOPS, SB144
  • Links
    NCBI Gene ID: 83590
    neXtProt AC: NX_Q9BVT8
    UniProt: Q9BVT8

  • Chr Location
    7q36.1; chr7:151081085-151083493 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show nocturnal hyperactivity, decreased REM and NREM sleep time during dark phase, reduced total body and abdominal fat, and increased monocyte count. Mice homozygous for a different null allele are resistant to etoposide-induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028958 Ensembl Gene Model | MGI Sequence Detail 2397 C57BL/6J ±  kb
    transcript ENSMUST00000238335 Ensembl | MGI Sequence Detail 1232 Not Applicable  
    polypeptide ENSMUSP00000158761 Ensembl | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000016470 transmembrane and ubiquitin-like domain-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR040352 Transmembrane and ubiquitin-like domain-containing protein 1/2
      IPR000626 Ubiquitin-like domain
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      Q9JMG3 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1927577
    References
    more
    • Summaries
      All 46
      Diseases 1
      Gene Ontology 4
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory