Lsm8 MGI Mouse Gene Detail - MGI:1923772 - LSM8 homolog, U6 small nuclear RNA associated

Symbol

Lsm8
Name

LSM8 homolog, U6 small nuclear RNA associated
Synonyms

2010003I05Rik, Lsm8

Feature Type

protein coding gene
IDs

MGI:1923772
NCBI Gene: 76522
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:18848634-18854051 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 8.16 cM
Mapping Data

2 experiments

SNPs within 2kb

219 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923772	protein coding gene	Chr6:18848578-18855750 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030477	protein coding gene	Chr6:16165563-16172760 (+)
A/J	MGP_AJ_G0030450	protein coding gene	Chr6:15487081-15494253 (+)
AKR/J	MGP_AKRJ_G0030377	protein coding gene	Chr6:16027583-16034755 (+)
BALB/cJ	MGP_BALBcJ_G0030459	protein coding gene	Chr6:15590165-15597337 (+)
C3H/HeJ	MGP_C3HHeJ_G0030173	protein coding gene	Chr6:15897542-15904714 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030914	protein coding gene	Chr6:16678306-16685478 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028125	protein coding gene	Chr6:14402356-14409312 (+)
CAST/EiJ	MGP_CASTEiJ_G0029575	protein coding gene	Chr6:15829640-15836789 (+)
CBA/J	MGP_CBAJ_G0030151	protein coding gene	Chr6:17237896-17245068 (+)
DBA/2J	MGP_DBA2J_G0030295	protein coding gene	Chr6:15418009-15425181 (+)
FVB/NJ	MGP_FVBNJ_G0030249	protein coding gene	Chr6:15249974-15257146 (+)
LP/J	MGP_LPJ_G0030382	protein coding gene	Chr6:16235209-16242406 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030285	protein coding gene	Chr6:18444711-18451883 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030944	protein coding gene	Chr6:15926290-15933462 (+)
PWK/PhJ	MGP_PWKPhJ_G0029289	protein coding gene	Chr6:15077425-15084653 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029125	protein coding gene	Chr6:15786373-15793514 (+)
WSB/EiJ	MGP_WSBEiJ_G0029651	protein coding gene	Chr6:15843998-15851171 (+)

Human Ortholog

LSM8, LSM8 homolog, U6 small nuclear RNA associated

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LSM8, LSM8 homolog, U6 small nuclear RNA associated
Synonyms

NAA38
Links

HGNC:20471

NCBI Gene ID: 51691

neXtProt AC: NX_O95777

UniProt: O95777
Chr Location

7q31.31; chr7:118184144-118204035 (+) GRCh38

MGI Vertebrate Homology

Lsm8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LSM8
Gene Tree

Lsm8

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

3
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

2
cDNA Data

49
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lsm8

ZFIN lsm8

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS39433.1

Ensembl

ENSMUSG00000044155 (Evidence)
NCBI Gene

76522

			Length	Strain/Species	Flank
genomic	76522	NCBI Gene Model \| MGI Sequence Detail	5418	C57BL/6J	± kb
transcript	NM_133939	RefSeq \| MGI Sequence Detail	768	Not Specified
polypeptide	Q6ZWM4	UniProt \| EBI \| MGI Sequence Detail	96	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009966 U6 snRNA-associated Sm-like protein LSm8

(term hierarchy)
InterPro Domains

IPR010920 LSM domain superfamily

IPR047575 Sm domain

IPR001163 Sm domain, eukaryotic/archaea-type

IPR034103 Sm-like protein Lsm8

IPR044642 U6 snRNA-associated Sm-like protein Lsm1/8

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All nucleic 50

cDNA 49

Primer pair 1

Microarray probesets 4

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MGI:2141667

Summaries

All 34

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lsm8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55110	Chr6:18848570-18848581 (+)	-58 bp
Tssr55111	Chr6:18848583-18848599 (+)	-43 bp
Tssr55112	Chr6:18848603-18848692 (+)	14 bp
Tssr55113	Chr6:18848696-18848708 (+)	68 bp
Tssr55114	Chr6:18853645-18853667 (+)	5,022 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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