About   Help   FAQ
Il34 Gene Detail
Summary
  • Symbol
    Il34
  • Name
    interleukin 34
  • Synonyms
    2010004A03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923777
    NCBI Gene: 76527
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111468461-111532556 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1515 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923777
 protein coding gene Chr8:111467809-111532579 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034127
 protein coding gene Chr8:113423286-113496207 (-)
A/J MGP_AJ_G0034106
 protein coding gene Chr8:108829027-108899125 (-)
AKR/J MGP_AKRJ_G0034033
 protein coding gene Chr8:112021756-112089088 (-)
BALB/cJ MGP_BALBcJ_G0034100
 protein coding gene Chr8:109021576-109088722 (-)
C3H/HeJ MGP_C3HHeJ_G0033811
 protein coding gene Chr8:112736007-112805958 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034620
 protein coding gene Chr8:117418309-117490546 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031562
 protein coding gene Chr8:101827542-101892987 (-)
CAST/EiJ MGP_CASTEiJ_G0033138
 protein coding gene Chr8:112348645-112421586 (-)
CBA/J MGP_CBAJ_G0033785
 protein coding gene Chr8:121384429-121478330 (-)
DBA/2J MGP_DBA2J_G0033940
 protein coding gene Chr8:108134601-108200764 (-)
FVB/NJ MGP_FVBNJ_G0033884
 protein coding gene Chr8:107092465-107156493 (-)
LP/J MGP_LPJ_G0034030
 protein coding gene Chr8:113615239-113685786 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033930
 protein coding gene Chr8:124318491-124388648 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034639
 protein coding gene Chr8:111988746-112058857 (-)
PWK/PhJ MGP_PWKPhJ_G0032841
 protein coding gene Chr8:107712811-107779373 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032680
 protein coding gene Chr8:110673762-110743492 (-)
WSB/EiJ MGP_WSBEiJ_G0033254
 protein coding gene Chr8:112675575-112747891 (-)



Homology
more
  • Human Ortholog
    IL34, interleukin 34
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL34, interleukin 34
  • Synonyms
    C16orf77, IL-34
  • Links
    NCBI Gene ID: 146433
    neXtProt AC: NX_Q6ZMJ4
    UniProt: Q6ZMJ4

  • Chr Location
    16q22.1; chr16:70579895-70660682 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced Langerhans cells and microglial cells in the skin and brain, respectively, with decreased susceptibility to type IV hypersensitivity reaction and fungal infection but increased susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    34
  • cDNA Data
    28
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031750 Ensembl Gene Model | MGI Sequence Detail 64096 C57BL/6J ±  kb
    transcript ENSMUST00000076846 Ensembl | MGI Sequence Detail 1709 Not Applicable  
    polypeptide ENSMUSP00000076120 Ensembl | MGI Sequence Detail 235 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 28
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142587
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341175 Ho A, et al., IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice. Biomed Pharmacother. 2023 Oct;166:115435
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory