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Msi2 Gene Detail
Summary
  • Symbol
    Msi2
  • Name
    musashi RNA-binding protein 2
  • Synonyms
    msi2h, Musashi2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923876
    NCBI Gene: 76626
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:88230208-88609197 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 52.40 cM, cytoband B5-C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923876
 protein coding gene Chr11:88230208-88609339 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018924
 protein coding gene Chr11:90055958-90454981 (-)
A/J MGP_AJ_G0018892
 protein coding gene Chr11:86559282-86941862 (-)
AKR/J MGP_AKRJ_G0018862
 protein coding gene Chr11:89189923-89580934 (-)
BALB/cJ MGP_BALBcJ_G0018865
 protein coding gene Chr11:86973461-87357129 (-)
C3H/HeJ MGP_C3HHeJ_G0018679
 protein coding gene Chr11:89216774-89616608 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019317
 protein coding gene Chr11:92797334-93198169 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016948
 protein coding gene Chr11:83577059-83968382 (-)
CAST/EiJ MGP_CASTEiJ_G0018234
 protein coding gene Chr11:89900227-90313916 (-)
CBA/J MGP_CBAJ_G0018650
 protein coding gene Chr11:96721778-97172345 (-)
DBA/2J MGP_DBA2J_G0018758
 protein coding gene Chr11:86117428-86497669 (-)
FVB/NJ MGP_FVBNJ_G0018747
 protein coding gene Chr11:85621531-86004049 (-)
LP/J MGP_LPJ_G0018828
 protein coding gene Chr11:90573670-90975493 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018774
 protein coding gene Chr11:96721229-97118186 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019357
 protein coding gene Chr11:89406521-89797935 (-)
PWK/PhJ MGP_PWKPhJ_G0018004
 protein coding gene Chr11:86959017-87351211 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017795
 protein coding gene Chr11:88993820-89380385 (-)
WSB/EiJ MGP_WSBEiJ_G0018283
 protein coding gene Chr11:89301107-89695754 (-)



Homology
more
  • Human Ortholog
    MSI2, musashi RNA binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSI2, musashi RNA binding protein 2
  • Synonyms
    MSI2H
  • Links
    NCBI Gene ID: 124540
    neXtProt AC: NX_Q96DH6
    UniProt: Q96DH6

  • Chr Location
    17q22; chr17:57255851-57701581 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 4 alleles in 4 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit lethality, decreased body size, and decreased hematopoietic stem cells. Mice homozygous for a conditional knock-out allele exhibit impaired hematopoietic stem cell physiology upon induction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    148
  • cDNA Data
    27
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76626 NCBI Gene Model | MGI Sequence Detail 378990 C57BL/6J ±  kb
    transcript NM_054043 RefSeq | MGI Sequence Detail 6505 C57BL/6  
    polypeptide Q920Q6 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000010672 RNA-binding protein Musashi homolog 2
      (term hierarchy)
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR034126 RNA-binding protein Musashi homologue, RNA recognition motif 2
      IPR000504 RNA recognition motif domain
    • GlyGen
      Q920Q6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 1
      cDNA 29
      Primer pair 4
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2144175, MGI:2144227, MGI:2144536
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 5
      Phenotypes 47
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346611 Banik J, et al., The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs. Sci Rep. 2024 Mar 11;14(1):5918
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory