Creld2 MGI Mouse Gene Detail - MGI:1923987 - cysteine-rich with EGF-like domains 2

Symbol

Creld2
Name

cysteine-rich with EGF-like domains 2
Synonyms

5730592L21Rik

Feature Type

protein coding gene
IDs

MGI:1923987
NCBI Gene: 76737
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:88703849-88710884 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.31 cM
Mapping Data

2 experiments

SNPs within 2kb

289 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923987	protein coding gene	Chr15:88703849-88710886 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022209	protein coding gene	Chr15:89978020-89985062 (+)
A/J	MGP_AJ_G0022168	protein coding gene	Chr15:86543252-86550280 (+)
AKR/J	MGP_AKRJ_G0022143	protein coding gene	Chr15:89106194-89113238 (+)
BALB/cJ	MGP_BALBcJ_G0022174	protein coding gene	Chr15:86642299-86649343 (+)
C3H/HeJ	MGP_C3HHeJ_G0021944	protein coding gene	Chr15:89086760-89093809 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022619	protein coding gene	Chr15:93241852-93248932 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020144	protein coding gene	Chr15:82776545-82783542 (+)
CAST/EiJ	MGP_CASTEiJ_G0021466	protein coding gene	Chr15:89871762-89878791 (+)
CBA/J	MGP_CBAJ_G0021911	protein coding gene	Chr15:96404110-96411167 (+)
DBA/2J	MGP_DBA2J_G0022038	protein coding gene	Chr15:85978974-85986400 (+)
FVB/NJ	MGP_FVBNJ_G0022017	protein coding gene	Chr15:85059554-85066580 (+)
LP/J	MGP_LPJ_G0022109	protein coding gene	Chr15:90130774-90137805 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022037	protein coding gene	Chr15:100850816-100857877 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022634	protein coding gene	Chr15:89128346-89136968 (+)
PWK/PhJ	MGP_PWKPhJ_G0021207	protein coding gene	Chr15:86040429-86047498 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021041	protein coding gene	Chr15:88874244-88881246 (+)
WSB/EiJ	MGP_WSBEiJ_G0021515	protein coding gene	Chr15:89619799-89626827 (+)

Human Ortholog

CRELD2, cysteine rich with EGF like domains 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRELD2, cysteine rich with EGF like domains 2
Links

HGNC:28150

NCBI Gene ID: 79174

neXtProt AC: NX_Q6UXH1

UniProt: Q6UXH1
Chr Location

22q13.33; chr22:49918167-49927540 (+) GRCh38

MGI Vertebrate Homology

Creld2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRELD2
Gene Tree

Creld2

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

1
Radiation induced

2
Targeted

9
Genomic Mutations

3 involving Creld2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a knock-out allele show increased susceptibility to hepatic steatosis after pharmacological ER stress induction, increased susceptibility to age-related hepatic steatosis, and decreased susceptibility to diet-induced hepatic steatosis. Females mice do not develop hepatic steatosis with progressing age.

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

858
Tissues

42
cDNA Data

47
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase creld2

ZFIN creld2

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All Sequences

34
RefSeq

2
UniProt

1
CCDS

CCDS27733.1

Ensembl

ENSMUSG00000023272 (Evidence)
NCBI Gene

76737

			Length	Strain/Species	Flank
genomic	76737	NCBI Gene Model \| MGI Sequence Detail	7036	C57BL/6J	± kb
transcript	NM_029720	RefSeq \| MGI Sequence Detail	1364	C57BL/6
polypeptide	Q9CYA0	UniProt \| EBI \| MGI Sequence Detail	350	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005865 protein disulfide isomerase CRELD2

(term hierarchy)
EC

5.3.4.1
InterPro Domains

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR006212 Furin-like repeat

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR002049 Laminin-type EGF domain

IPR049883 NOTCH1 EGF-like calcium-binding domain

IPR051146 Phosphatidylserine Receptors and Protein Disulfide Isomerases
GlyGen

Q9CYA0 2 sites, 3 N-linked glycans (1 site)

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All nucleic 49

cDNA 47

Primer pair 2

Microarray probesets 2

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MGI:2146312

Summaries

All 66

Developmental Gene Expression 5

Diseases 1

Gene Ontology 5

Phenotypes 35
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Creld2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132615	Chr15:88703787-88703887 (+)	-12 bp
Tssr132616	Chr15:88703897-88703920 (+)	60 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24