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Trdn Gene Detail
Summary
  • Symbol
    Trdn
  • Name
    triadin
  • Synonyms
    2310045H21Rik, EG432451, triadin 1, triadin-1, triadin 2, triadin-2, triadin 3, triadin-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924007
    NCBI Gene: 76757
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:32959479-33352705 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 18.37 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924007
 protein coding gene Chr10:32956550-33352705 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017125
 protein coding gene Chr10:31368059-31785353 (+)
A/J MGP_AJ_G0017102
 protein coding gene Chr10:30437748-30839257 (+)
AKR/J MGP_AKRJ_G0017062
 protein coding gene Chr10:30901862-31311667 (+)
BALB/cJ MGP_BALBcJ_G0017065
 protein coding gene Chr10:30499959-30911808 (+)
C3H/HeJ MGP_C3HHeJ_G0016885
 protein coding gene Chr10:31199788-31604169 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017523
 protein coding gene Chr10:32320108-32732093 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015220
 protein coding gene Chr10:28849658-29243250 (+)
CAST/EiJ MGP_CASTEiJ_G0016464
 protein coding gene Chr10:31295215-31719053 (+)
CBA/J MGP_CBAJ_G0016859
 protein coding gene Chr10:33834595-34303998 (+)
DBA/2J MGP_DBA2J_G0016964
 protein coding gene Chr10:30124541-30524377 (+)
FVB/NJ MGP_FVBNJ_G0016959
 protein coding gene Chr10:29671330-30067308 (+)
LP/J MGP_LPJ_G0017041
 protein coding gene Chr10:31357465-31775267 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016989
 protein coding gene Chr10:34170339-34720730 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017559
 protein coding gene Chr10:30860291-31266449 (+)
PWK/PhJ MGP_PWKPhJ_G0016246
 protein coding gene Chr10:29917828-30317028 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016029
 protein coding gene Chr10:30777719-31185100 (+)
WSB/EiJ MGP_WSBEiJ_G0016527
 protein coding gene Chr10:31049022-31478720 (+)



Homology
more
  • Human Ortholog
    TRDN, triadin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRDN, triadin
  • Synonyms
    CARDAR, CPVT5, TDN, TRISK
  • Links
    NCBI Gene ID: 10345
    neXtProt AC: NX_Q13061
    UniProt: Q13061

  • Chr Location
    6q22.31; chr6:123216339-123637189 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TRDN associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a loss of transverse orientation of triads within skeletal muscle cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    29
  • cDNA Data
    19
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76757 NCBI Gene Model | MGI Sequence Detail 393227 C57BL/6J ±  kb
    transcript NM_029726 RefSeq | MGI Sequence Detail 4514 C57BL/6  
    polypeptide E9Q9K5 UniProt | EBI | MGI Sequence Detail 693 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:3646337
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:322531 Manno C, et al., Quantification of the calcium signaling deficit in muscles devoid of triadin. PLoS One. 2022;17(2):e0264146
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory