Csta2 MGI Mouse Gene Detail - MGI:1924020 - cystatin A family member 2

Symbol

Csta2
Name

cystatin A family member 2
Synonyms

2010005H15Rik

Feature Type

protein coding gene
IDs

MGI:1924020
NCBI Gene: 76770
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:36041932-36077813 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 25.44 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

716 from dbSNP Build 142
Strain Annotations

13

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924020	protein coding gene	Chr16:36041838-36077813 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022787	protein coding gene	Chr16:34778106-34792147 (-)
A/J	MGP_AJ_G0022748	protein coding gene	Chr16:32884800-32886508 (+)
AKR/J	MGP_AKRJ_G0022722	protein coding gene	Chr16:34106761-34126692 (+)
BALB/cJ	MGP_BALBcJ_G0022752	protein coding gene	Chr16:33158849-33163617 (-)
C3H/HeJ	MGP_C3HHeJ_G0022516	protein coding gene	Chr16:34282966-34302498 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023197	protein coding gene	Chr16:35422876-35427159 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0022486	protein coding gene	Chr16:37127889-37134919 (-)
DBA/2J	MGP_DBA2J_G0022619	protein coding gene	Chr16:32796362-32815688 (+)
FVB/NJ	MGP_FVBNJ_G0022595	protein coding gene	Chr16:32980342-32985049 (-)
LP/J	MGP_LPJ_G0022687	protein coding gene	Chr16:34443157-34472582 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022612	protein coding gene	Chr16:36014289-36016017 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023215	protein coding gene	Chr16:34271527-34276224 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

CSTA, cystatin A

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSTA, cystatin A
Synonyms

AREI, PSS4, STF1, STFA
Links

HGNC:2481

NCBI Gene ID: 1475

neXtProt AC: NX_P01040

UniProt: P01040
Chr Location

3q21.1; chr3:122325248-122341969 (+) GRCh38

MGI Vertebrate Homology

Csta2 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CSTA
Gene Tree

Csta2

Diseases

1 with human CSTA associations

				Human Disease	Mouse Models
				peeling skin syndrome 4 IDs peeling skin syndrome 4 DOID:0070523 MESH:C564309 OMIM:607936

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype reference

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

5 strains or lines available

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All GO Annotations

15
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

4
UniProt

1
CCDS

CCDS37330.1

Ensembl

ENSMUSG00000095620 (Evidence)
NCBI Gene

76770

			Length	Strain/Species	Flank
genomic	76770	NCBI Gene Model \| MGI Sequence Detail	35882	C57BL/6J	± kb
transcript	NM_029733	RefSeq \| MGI Sequence Detail	528	Not Specified
polypeptide	NP_001371019	RefSeq \| MGI Sequence Detail	97	C57BL/6

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UniProt

1 Sequence
InterPro Domains

IPR000010 Cystatin domain

IPR046350 Cystatin superfamily

IPR001713 Proteinase inhibitor I25A, stefin

IPR018073 Proteinase inhibitor I25, cystatin, conserved site

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All nucleic 4

cDNA 4

Microarray probesets 3

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MGI:6274736

Summaries

All 18

Gene Ontology 2

Phenotypes 1
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573

TSS for Csta2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138257	Chr16:36073242-36073247 (+)	31,313 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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