Nubpl MGI Mouse Gene Detail - MGI:1924076 - nucleotide binding protein-like

Symbol

Nubpl
Name

nucleotide binding protein-like
Synonyms

2410170E07Rik

Feature Type

protein coding gene
IDs

MGI:1924076
NCBI Gene: 76826
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:52144529-52357753 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 22.11 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

4551 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924076	protein coding gene	Chr12:52144520-52359527 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019731	protein coding gene	Chr12:50929837-51140783 (+)
A/J	MGP_AJ_G0019693	protein coding gene	Chr12:49119060-49320903 (+)
AKR/J	MGP_AKRJ_G0019664	protein coding gene	Chr12:50601657-50823775 (+)
BALB/cJ	MGP_BALBcJ_G0019671	protein coding gene	Chr12:49398525-49601521 (+)
C3H/HeJ	MGP_C3HHeJ_G0019474	protein coding gene	Chr12:50695682-50913027 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020119	protein coding gene	Chr12:52501785-52716345 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017742	protein coding gene	Chr12:47513366-47701501 (+)
CAST/EiJ	MGP_CASTEiJ_G0019027	protein coding gene	Chr12:45754700-45951878 (+)
CBA/J	MGP_CBAJ_G0019446	protein coding gene	Chr12:54291832-54512034 (+)
DBA/2J	MGP_DBA2J_G0019560	protein coding gene	Chr12:48993385-49199061 (+)
FVB/NJ	MGP_FVBNJ_G0019549	protein coding gene	Chr12:48430887-48634538 (+)
LP/J	MGP_LPJ_G0019632	protein coding gene	Chr12:50971564-51176930 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019585	protein coding gene	Chr12:55908653-56158250 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020157	protein coding gene	Chr12:50101001-50313831 (+)
PWK/PhJ	MGP_PWKPhJ_G0018794	protein coding gene	Chr12:43581017-43771441 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018588	protein coding gene	Chr12:44700033-44894453 (+)
WSB/EiJ	MGP_WSBEiJ_G0019078	protein coding gene	Chr12:50594818-50803128 (+)

Human Ortholog

NUBPL, NUBP iron-sulfur cluster assembly factor, mitochondrial

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUBPL, NUBP iron-sulfur cluster assembly factor, mitochondrial
Synonyms

C14orf127, huInd1, IND1, MC1DN21
Links

HGNC:20278

NCBI Gene ID: 80224

neXtProt AC: NX_Q8TB37

UniProt: Q8TB37
Chr Location

14q12; chr14:31489956-31861224 (+) GRCh38

MGI Vertebrate Homology

Nubpl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUBPL
Gene Tree

Nubpl

Diseases

1 with human NUBPL associations

				Human Disease	Mouse Models
				nuclear type mitochondrial complex I deficiency 21 IDs nuclear type mitochondrial complex I deficiency 21 DOID:0112088 OMIM:618242

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

3
Genomic Mutations

1 involving Nubpl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit defects in placentation with abnormal trophoblast layer formation, abnormal trophoblast giant cell size and morphology, and complete embryonic lethality during organogenesis.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nubpl

ZFIN nubpl

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All Sequences

46
RefSeq

6
UniProt

4
CCDS

CCDS36442.2

Ensembl

ENSMUSG00000035142 (Evidence)
NCBI Gene

76826

			Length	Strain/Species	Flank
genomic	76826	NCBI Gene Model \| MGI Sequence Detail	213225	C57BL/6J	± kb
transcript	NM_029760	RefSeq \| MGI Sequence Detail	1230	C57BL/6
polypeptide	Q9CWD8	UniProt \| EBI \| MGI Sequence Detail	319	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011478 nucleotide-binding protein-like

(term hierarchy)
InterPro Domains

IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35

IPR000808 Iron-sulfur cluster carrier protein-like, conserved site

IPR044304 Iron-sulfur protein NUBPL-like

IPR019591 Mrp/NBP35 ATP-binding protein

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 16

cDNA 16

Microarray probesets 3

Summaries

All 35

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nubpl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113428	Chr12:52144512-52144519 (+)	-13 bp
Tssr113429	Chr12:52144520-52144558 (+)	10 bp
Tssr113430	Chr12:52263439-52263443 (+)	118,912 bp
Tssr113431	Chr12:52312517-52312543 (+)	168,001 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24