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Memo1 Gene Detail
Summary
  • Symbol
    Memo1
  • Name
    mediator of cell motility 1
  • Synonyms
    0610016J10Rik, D930048L02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924140
    NCBI Gene: 76890
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:74506031-74602516 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 45.63 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924140
 protein coding gene Chr17:74493759-74602677 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024024
 protein coding gene Chr17:76800309-76915512 (-)
A/J MGP_AJ_G0023982
 protein coding gene Chr17:74466863-74563763 (-)
AKR/J MGP_AKRJ_G0023951
 protein coding gene Chr17:75523511-75630517 (-)
BALB/cJ MGP_BALBcJ_G0023984
 protein coding gene Chr17:74368888-74469040 (-)
C3H/HeJ MGP_C3HHeJ_G0023747
 protein coding gene Chr17:76466657-76566294 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024429
 protein coding gene Chr17:79571495-79670107 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021873
 protein coding gene Chr17:70115895-70212904 (-)
CAST/EiJ MGP_CASTEiJ_G0023228
 protein coding gene Chr17:76958577-77064746 (-)
CBA/J MGP_CBAJ_G0023722
 protein coding gene Chr17:82904593-83019572 (-)
DBA/2J MGP_DBA2J_G0023851
 protein coding gene Chr17:73065955-73161575 (-)
FVB/NJ MGP_FVBNJ_G0023817
 protein coding gene Chr17:72560027-72654820 (-)
LP/J MGP_LPJ_G0023933
 protein coding gene Chr17:77581879-77681930 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023845
 protein coding gene Chr17:82708622-82828603 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024473
 protein coding gene Chr17:76002529-76108672 (-)
PWK/PhJ MGP_PWKPhJ_G0022974
 protein coding gene Chr17:72432655-72530388 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022785
 protein coding gene Chr17:72682758-72799701 (-)
WSB/EiJ MGP_WSBEiJ_G0023295
 protein coding gene Chr17:76873937-76976277 (-)



Homology
more
  • Human Ortholog
    MEMO1, mediator of cell motility 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEMO1, mediator of cell motility 1
  • Synonyms
    C2orf4, CGI-27, MEMO, NS5ATP7
  • Links
    NCBI Gene ID: 51072
    neXtProt AC: NX_Q9Y316
    UniProt: Q9Y316

  • Chr Location
    2p22.3; chr2:31865060-32011230 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 5 alleles in 6 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles display strain background dependent lethality and defects in vasculogenesis or endochondral bone development. Mice homozygous for a floxed allele activated postnatally exhibit a reduced life span, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, loss of spermatozoa in the epididymis and increased active vitamin D.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1057
  • Tissues
    159
  • cDNA Data
    63
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058704 Ensembl Gene Model | MGI Sequence Detail 96486 C57BL/6J ±  kb
    transcript ENSMUST00000233514 Ensembl | MGI Sequence Detail 3163 Not Applicable  
    polypeptide ENSMUSP00000156607 Ensembl | MGI Sequence Detail 297 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 64
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2445124
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 7
      Gene Ontology 3
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory