Rnft1 MGI Mouse Gene Detail - MGI:1924142 - ring finger protein, transmembrane 1

Symbol

Rnft1
Name

ring finger protein, transmembrane 1
Synonyms

0610013E23Rik

Feature Type

protein coding gene
IDs

MGI:1924142
NCBI Gene: 76892
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:86375483-86389833 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.82 cM
Mapping Data

2 experiments

SNPs within 2kb

296 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924142	protein coding gene	Chr11:86375483-86389851 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018889	protein coding gene	Chr11:88041278-88057684 (+)
A/J	MGP_AJ_G0018856	protein coding gene	Chr11:84653311-84672294 (+)
AKR/J	MGP_AKRJ_G0018826	protein coding gene	Chr11:87189809-87205605 (+)
BALB/cJ	MGP_BALBcJ_G0018829	protein coding gene	Chr11:85045218-85059888 (+)
C3H/HeJ	MGP_C3HHeJ_G0018643	protein coding gene	Chr11:87219468-87234381 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019281	protein coding gene	Chr11:90710008-90724377 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016914	protein coding gene	Chr11:81688478-81702751 (+)
CAST/EiJ	MGP_CASTEiJ_G0018198	protein coding gene	Chr11:87899828-87916239 (+)
CBA/J	MGP_CBAJ_G0018614	protein coding gene	Chr11:94522684-94539244 (+)
DBA/2J	MGP_DBA2J_G0018722	protein coding gene	Chr11:84229263-84244461 (+)
FVB/NJ	MGP_FVBNJ_G0018711	protein coding gene	Chr11:83732496-83747031 (+)
LP/J	MGP_LPJ_G0018792	protein coding gene	Chr11:88532641-88549476 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018738	protein coding gene	Chr11:94632228-94647733 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019321	protein coding gene	Chr11:87437080-87451601 (+)
PWK/PhJ	MGP_PWKPhJ_G0017967	protein coding gene	Chr11:85025513-85039523 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017759	protein coding gene	Chr11:86988369-87006444 (+)
WSB/EiJ	MGP_WSBEiJ_G0018249	protein coding gene	Chr11:87309472-87324303 (+)

Human Ortholog

RNFT1, ring finger protein, transmembrane 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNFT1, ring finger protein, transmembrane 1
Synonyms

PTD016
Links

HGNC:30206

NCBI Gene ID: 51136

neXtProt AC: NX_Q5M7Z0

UniProt: Q5M7Z0
Chr Location

17q23.1; chr17:59952240-59964761 (-) GRCh38

MGI Vertebrate Homology

Rnft1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNFT1
Gene Tree

Rnft1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Targeted

1
Genomic Mutations

2 involving Rnft1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnft1

ZFIN rnft1

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS25200.1

Ensembl

ENSMUSG00000020521 (Evidence)
NCBI Gene

76892

			Length	Strain/Species	Flank
genomic	76892	NCBI Gene Model \| MGI Sequence Detail	14351	C57BL/6J	± kb
transcript	NM_029788	RefSeq \| MGI Sequence Detail	4434	C57BL/6
polypeptide	Q9DCN7	UniProt \| EBI \| MGI Sequence Detail	395	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030440 E3 ubiquitin-protein ligase RNFT1

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR044235 E3 ubiquitin-protein ligase 1/2

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 8

cDNA 8

Microarray probesets 5

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MGI:2144450

Summaries

All 37

Gene Ontology 5

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnft1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103868	Chr11:86375450-86375469 (+)	-23 bp
Tssr103869	Chr11:86375473-86375542 (+)	25 bp
Tssr103870	Chr11:86375545-86375557 (+)	68 bp
Tssr103871	Chr11:86375565-86375576 (+)	88 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24