Cers2 MGI Mouse Gene Detail - MGI:1924143

Symbol

Cers2
Name

ceramide synthase 2
Synonyms

0610013I17Rik, CerS2, Lass2, Trh3

Feature Type

protein coding gene
IDs

MGI:1924143
NCBI Gene: 76893
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr3:95222102-95230910 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

198 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924143	protein coding gene	Chr3:95222077-95230910 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027582	protein coding gene	Chr3:96039141-96047852 (+)
A/J	MGP_AJ_G0027541	protein coding gene	Chr3:93058141-93070353 (+)
AKR/J	MGP_AKRJ_G0027508	protein coding gene	Chr3:95213314-95222052 (+)
BALB/cJ	MGP_BALBcJ_G0027553	protein coding gene	Chr3:92834659-92843427 (+)
C3H/HeJ	MGP_C3HHeJ_G0027286	protein coding gene	Chr3:95490304-95499007 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028001	protein coding gene	Chr3:99596037-99606688 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025341	protein coding gene	Chr3:89421217-89430068 (+)
CAST/EiJ	MGP_CASTEiJ_G0026736	protein coding gene	Chr3:94784212-94794676 (+)
CBA/J	MGP_CBAJ_G0027263	protein coding gene	Chr3:103217267-103228697 (+)
DBA/2J	MGP_DBA2J_G0027402	protein coding gene	Chr3:92348681-92357775 (+)
FVB/NJ	MGP_FVBNJ_G0027373	protein coding gene	Chr3:90424625-90434006 (+)
LP/J	MGP_LPJ_G0027511	protein coding gene	Chr3:97344378-97354443 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027400	protein coding gene	Chr3:109316703-109326391 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028055	protein coding gene	Chr3:94863316-94873060 (+)
PWK/PhJ	MGP_PWKPhJ_G0026464	protein coding gene	Chr3:92232297-92241131 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026285	protein coding gene	Chr3:93160418-93169237 (+)
WSB/EiJ	MGP_WSBEiJ_G0026818	protein coding gene	Chr3:95251374-95260158 (+)

Human Ortholog

CERS2, ceramide synthase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CERS2, ceramide synthase 2
Synonyms

L3, LASS2, SP260, TMSG1
Links

HGNC:14076

NCBI Gene ID: 29956

neXtProt AC: NX_Q96G23

UniProt: Q96G23
Chr Location

1q21.3; chr1:150960583-150975003 (-) GRCh38

MGI Vertebrate Homology

Cers2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CERS2
Protein SuperFamily

LAG1_LAC1
Gene Tree

Cers2

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
2 images
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

38
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Cers2
Incidental Mutations

APF
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit abnormal ceramide species and myelin sheath defects and develop hepatocellular carcinoma.

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All GO Annotations

24
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

14
cDNA Data

243
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cers2

ZFIN cers2a, cers2b

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All Sequences

62
RefSeq

8
UniProt

4
CCDS

CCDS17612.1

Ensembl

ENSMUSG00000015714 (Evidence)
NCBI Gene

76893

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015714	Ensembl Gene Model \| MGI Sequence Detail	8809	C57BL/6J	± kb
transcript	ENSMUST00000015858	Ensembl \| MGI Sequence Detail	2216	Not Applicable
polypeptide	ENSMUSP00000015858	Ensembl \| MGI Sequence Detail	380	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009678 ceramide synthase 2

(term hierarchy)
EC

2.3.1.24, 2.3.1.297
InterPro Domains

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR016439 Sphingosine N-acyltransferase Lag1/Lac1-like

IPR006634 TRAM/LAG1/CLN8 homology domain
GlyGen

Q924Z4 2 sites, 3 N-linked glycans (1 site), 1 O-linked glycan (1 site)

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All nucleic 248

cDNA 244

Primer pair 4

Microarray probesets 3

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MGI:2139649

Summaries

All 92

Developmental Gene Expression 9

Diseases 1

Gene Ontology 13

Phenotypes 42
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:352590 Zhu Q, et al., PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels. Nat Metab. 2024 Jul;6(7):1347-1366

TSS for Cers2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30537	Chr3:95222143-95222177 (+)	58 bp
Tssr30538	Chr3:95222551-95222584 (+)	466 bp
Tssr30539	Chr3:95222593-95222613 (+)	501 bp
Tssr30540	Chr3:95226093-95226104 (+)	3,997 bp
Tssr30541	Chr3:95226112-95226130 (+)	4,019 bp
Tssr30542	Chr3:95226135-95226181 (+)	4,056 bp
Tssr30543	Chr3:95227279-95227288 (+)	5,182 bp
Tssr30544	Chr3:95227458-95227476 (+)	5,365 bp
Tssr30545	Chr3:95227478-95227514 (+)	5,394 bp
Tssr30546	Chr3:95227781-95227804 (+)	5,691 bp
Tssr30547	Chr3:95228303-95228325 (+)	6,212 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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